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176880 Anisomycin, Streptomyces griseolus - CAS 22862-76-6 - Calbiochem

Anisomycin, Streptomyces griseolus, CAS 22862-76-6, acts as an inhibitor of protein synthesis at the translation step. Strongly activates JNK/SAPK and p38 MAP kinase in mammalian cells.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate

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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      22862-76-6C₁₄H₁₉NO₄
      Description
      OverviewStrongly activates stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase in mammalian cells. Synergizes with growth factors to induce c-fos and c-jun by acting as a potent signaling agonist. An inhibitor of protein synthesis at the translation step. Also known to induce apoptosis in the human monoblastoid cell line, U937.
      Catalogue Number176880
      Brand Family Calbiochem®
      Synonyms2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate
      References
      ReferencesHazzalin, C.A., et al. 1998. Mol. Cell. Biol. 18, 1844.
      Kardalinou, E., et al. 1994. Mol. Cell. Biol. 14, 1066.
      Kyriakis, J.M., et al. 1994. Nature 369, 156.
      Sanchez, I., et al. 1994. Nature 372, 794.
      Shinohara, K., and Oka, T. 1994. NeuroReport 5, 2201.
      Kochi, S. K., and Collier, R.J. 1993. Exp. Cell Res. 208, 296.
      Product Information
      CAS number22862-76-6
      FormWhite solid
      Hill FormulaC₁₄H₁₉NO₄
      Chemical formulaC₁₄H₁₉NO₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationAnisomycin, Streptomyces griseolus, CAS 22862-76-6, acts as an inhibitor of protein synthesis at the translation step. Strongly activates JNK/SAPK and p38 MAP kinase in mammalian cells.
      Biological Information
      Purity≥98% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSBZ9800000
      Safety Information
      R PhraseR: 23/24/25

      Toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36/37/39-45

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution store in the refrigerator (4°C). DMSO stock solutions are stable for up to 6 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      176880 0

      Documentation

      Anisomycin, Streptomyces griseolus - CAS 22862-76-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Anisomycin, Streptomyces griseolus - CAS 22862-76-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      176880

      References

      Reference overview
      Hazzalin, C.A., et al. 1998. Mol. Cell. Biol. 18, 1844.
      Kardalinou, E., et al. 1994. Mol. Cell. Biol. 14, 1066.
      Kyriakis, J.M., et al. 1994. Nature 369, 156.
      Sanchez, I., et al. 1994. Nature 372, 794.
      Shinohara, K., and Oka, T. 1994. NeuroReport 5, 2201.
      Kochi, S. K., and Collier, R.J. 1993. Exp. Cell Res. 208, 296.

      Brochure

      Title
      Antibiotics Profiler
      MAPK Pathway Poster ( 750 KB )
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-June-2009 RFH
      Synonyms2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate
      DescriptionActivates p54 and MAP kinases. Involved in the activation of stress-activated protein kinases (SAPKs). Synergizes with growth factors to induce c-fos and c-jun by acting as a potent signaling agonist. An inhibitor of protein synthesis at the translation step. Also known to induce apoptosis in the human monoblastoid cell line, U937.
      FormWhite solid
      CAS number22862-76-6
      RTECSBZ9800000
      Chemical formulaC₁₄H₁₉NO₄
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (100 mg/ml) or Methanol (50 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution store in the refrigerator (4°C). DMSO stock solutions are stable for up to 6 months at 4°C.
      Toxicity Toxic
      Merck USA index14, 670
      ReferencesHazzalin, C.A., et al. 1998. Mol. Cell. Biol. 18, 1844.
      Kardalinou, E., et al. 1994. Mol. Cell. Biol. 14, 1066.
      Kyriakis, J.M., et al. 1994. Nature 369, 156.
      Sanchez, I., et al. 1994. Nature 372, 794.
      Shinohara, K., and Oka, T. 1994. NeuroReport 5, 2201.
      Kochi, S. K., and Collier, R.J. 1993. Exp. Cell Res. 208, 296.