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CP26 Anti-Integrin β₁ Mouse mAb (4B7)

Anti-Integrin β₁ Mouse mAb (4B7) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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CP26
  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityHostAntibody Type
      HMMonoclonal Antibody
      Description
      Overview

      This product has been discontinued.



      Recognizes the β1 integrin subunit in A431 and Jurkat cells.
      Catalogue NumberCP26
      Brand Family Calbiochem®
      References
      ReferencesAkiyama, S.K. 1996. Hum. Cell. 9, 181.
      Farnoud, M.R. et al. 1996. Int. J. Cancer 67, 45.
      Morimoto, C. and Tachibana, K. 1996. Hum. Cell. 9, 163.
      Webb, D.L. et al. 1996. J. Cell. Biochem. 61, 127.
      Schaller, M.D. et al. 1995. J. Cell. Biol. 130, 1181.
      Akiyama, S.K. et al. 1994. J. Biol. Chem. 269, 15961.
      Albelda, S.M. 1993. Lab. Invest. 68, 4.
      Evans, C.W. 1992. Cell. Biol. Int. Rep. 16, 1.
      Albelds, S.M. and Buck, C.A. 1990. FASEB J. 4, 2868.
      Product Information
      FormLiquid
      FormulationIn 50 mM sodium phosphate buffer, 50% glycerol.
      Positive controlA-431 or Jurkat cells or skin tissue
      PreservativeNone
      Quality LevelMQ100
      Applications
      Application ReferencesNeutralization Studies Heise, T. and Dersch, P. 2006. Proc. Natl. Acad. Sci. USA 103, 3375.
      Key Applications Frozen Sections
      Immunofluorescence
      Immunoprecipitation
      Not Western Blot
      Neutralization Studies
      Paraffin Sections
      Application NotesFrozen Sections (2 µg/ml)
      Immunofluorescence (2.5 µg/ml)
      Immunoprecipitation (1 µg/sample)
      Paraffin Sections (2 µg/ml, no pre-treatment required)
      Immunoblotting (not recommended)
      Neutralization Studies (see application references)
      Application CommentsAntibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogenrecombinant, human β1 integrin
      ImmunogenHuman
      Clone4B7
      HostMouse
      IsotypeIgG₁
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      CP26 0

      Documentation

      Anti-Integrin β₁ Mouse mAb (4B7) SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Integrin β₁ Mouse mAb (4B7) Certificates of Analysis

      TitleLot Number
      CP26

      References

      Reference overview
      Akiyama, S.K. 1996. Hum. Cell. 9, 181.
      Farnoud, M.R. et al. 1996. Int. J. Cancer 67, 45.
      Morimoto, C. and Tachibana, K. 1996. Hum. Cell. 9, 163.
      Webb, D.L. et al. 1996. J. Cell. Biochem. 61, 127.
      Schaller, M.D. et al. 1995. J. Cell. Biol. 130, 1181.
      Akiyama, S.K. et al. 1994. J. Biol. Chem. 269, 15961.
      Albelda, S.M. 1993. Lab. Invest. 68, 4.
      Evans, C.W. 1992. Cell. Biol. Int. Rep. 16, 1.
      Albelds, S.M. and Buck, C.A. 1990. FASEB J. 4, 2868.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-March-2008 JSW
      ApplicationFrozen Sections (2 µg/ml)
      Immunofluorescence (2.5 µg/ml)
      Immunoprecipitation (1 µg/sample)
      Paraffin Sections (2 µg/ml, no pre-treatment required)
      Immunoblotting (not recommended)
      Neutralization Studies (see application references)
      DescriptionPurified mouse monoclonal antibody generated by immunizing mice with the specified immunogen and fusing splenocytes with Sp2/0 mouse myeloma cells. Recognizes the β1 integrin subunit.
      BackgroundThe integrins are a family of more than 23 heterodimeric transmembrane proteins that mediate cell-cell adhesions as well as cell-substratum adhesions and signal transduction processes. Expressed on essentially all cells as an alpha-beta dimeric protein, alterations in the integrin structure leading to changes in adhesive properties have important implications for tumor invasiveness and progression. The majority of the protein is found in the globular extracellular domain with the intracellular domain only composed of 60 amino acids or less. The beta 1 integrin is found widely distributed and is one of the subunits composing the major fibronectin receptor (FNR) along with the alpha 5 integrin. The beta 1 integrin has been shown to have a direct as well as a regulatory role in ligand binding and subsequent signal transduction. Upon ligand binding there is initiated a signal transduction cascade involving the phosphorylation of the integrin molecule itself as well as any of a number of different substrates including pp125FAK, PLCγ, MAP kinase and others. In addition to the role played in normal cell-cell interactions and development, integrins play an important role in the etiology of cancer.
      HostMouse
      Immunogen speciesHuman
      Immunogenrecombinant, human β1 integrin
      Clone4B7
      IsotypeIgG₁
      Specieshuman, not mouse, not rat
      Positive controlA-431 or Jurkat cells or skin tissue
      FormLiquid
      FormulationIn 50 mM sodium phosphate buffer, 50% glycerol.
      Concentration Label Please refer to vial label for lot-specific concentration
      PreservativeNone
      CommentsAntibody should be titrated for optimal results in individual systems.
      Storage Protect from moisture
      Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesAkiyama, S.K. 1996. Hum. Cell. 9, 181.
      Farnoud, M.R. et al. 1996. Int. J. Cancer 67, 45.
      Morimoto, C. and Tachibana, K. 1996. Hum. Cell. 9, 163.
      Webb, D.L. et al. 1996. J. Cell. Biochem. 61, 127.
      Schaller, M.D. et al. 1995. J. Cell. Biol. 130, 1181.
      Akiyama, S.K. et al. 1994. J. Biol. Chem. 269, 15961.
      Albelda, S.M. 1993. Lab. Invest. 68, 4.
      Evans, C.W. 1992. Cell. Biol. Int. Rep. 16, 1.
      Albelds, S.M. and Buck, C.A. 1990. FASEB J. 4, 2868.
      Application referencesNeutralization Studies Heise, T. and Dersch, P. 2006. Proc. Natl. Acad. Sci. USA 103, 3375.