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04-1584 Anti-Interleukin-2 (IL-2) Antibody, clone 3F9

Detect Interleukin-2 (IL-2) using this Anti-Interleukin-2 (IL-2) Antibody, clone 3F9 validated for use in WB.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Cytokines & Cytokine Receptors Gene Symbol: IL2, IL-2, TCGF UniProt Number: P60568
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04-1584
100 µg  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-1584
      DescriptionAnti-Interleukin-2 (IL-2) Antibody, clone 3F9
      Alternate Names
      • interleukin 2
      • involved in regulation of T-cell clonal expansion
      • aldesleukin
      • T cell growth factor
      • lymphokine
      • Aldesleukin
      • interleukin-2
      • T-cell growth factor
      Background InformationInterleukin-2 (IL-2) is commonly considered a pro-inflammatory cytokine that stimulated T-cell-dependent immune reactions and control regulatory T cells or Tregs. Structurally, IL-2 is thought to have a 4-helix-bundle-type fold and uses a novel type I cytokine receptor (IL-21R) with the common gamma chain cytokine receptor. IL-2 also may intensify Th1-mediated diseases, including autoimmune arthritis and may also be interesting clinical targets for those diseases. IL-2 has also been implicated as a possible therapy for infection and cancer. Anti-tumor therapies that include a combination of recombinant IL-2 and recombinant interferon alpha have been promising in clinical studies.
      References
      Product Information
      FormatPurified
      Control
      • Human IL-2 recombinant protein
      PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Interleukin-2 (IL-2) using this Anti-Interleukin-2 (IL-2) Antibody, clone 3F9 validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenFull length recombinant protein corresponding to human IL-2.
      CloneAB12.38.35C3.3F9
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq].
      Gene Symbol
      • IL2
      • IL-2
      • TCGF
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

      SUBCELLULAR LOCATION: Secreted.

      INVOLVEMENT IN DISEASE: Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

      PHARMACEUTICAL USE: Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma.

      SEQUENCE SIMILARITIES: Belongs to the IL-2 family.

      SEQUENCE CAUTION: The sequence AAA59140.1 differs from that shown. Reason: Erroneous initiation.
      Molecular Weight~15 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in lysate from cells expressing human IL-2 recombinant protein.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected 10 µg of human IL-2 recombinant protein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      04-1584 04053252646102

      Documentation

      Anti-Interleukin-2 (IL-2) Antibody, clone 3F9 Certificates of Analysis

      TitleLot Number
      Anti-Interleukin-2 (IL-2), clone 3F9 - 2073636 2073636
      Anti-Interleukin-2 (IL-2), clone 3F9 - 3494044 3494044
      Anti-Interleukin-2 (IL-2), clone 3F9 - NRG1843057 NRG1843057
      Anti-Interleukin-2 (IL-2), clone 3F9 -2567156 2567156
      Anti-Interleukin-2 (IL-2), clone 3F9 -2659576 2659576
      Anti-Interleukin-2 (IL-2), clone 3F9 -2665773 2665773
      Anti-Interleukin-2 (IL-2), clone 3F9 -2708943 2708943
      Anti-Interleukin-2 (IL-2), clone 3F9 -2786326 2786326
      Anti-Interleukin-2 (IL-2), clone 3F9 Monoclonal Antibody 3030316
      Anti-Interleukin-2 (IL-2), clone 3F9 Monoclonal Antibody 3137668