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ABE1414 Anti-MEIOB Antibody

This Anti-MEIOB Antibody is validated for use in Western Blotting and Immunoprecipitation and Immunocytochemistry for the detection of MEIOB.

Anti-MEIOB Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Nuclear Receptors Gene Symbol: Meiob UniProt Number: Q9D513
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ABE1414
100 µL  
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      Overview

      Replacement Information

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWB, IP, ICCRbSerumPolyclonal Antibody
      Description
      Catalogue NumberABE1414
      DescriptionAnti-MEIOB Antibody
      Alternate Names
      • Meiosis-specific with OB domain-containing protein
      • Protein expressed in male leptotene and zygotene spermatocytes 675
      • MLZ-675
      Background InformationMEIOB is a single stranded binding protein required for proper homologous recombination in meiosis I. MEIOB is required for proper DNA strand repair at double strand breaks and faithful synapsis of the chromosomes. MEIOB is also required for successful completion of meiotic recombination and is part of a multiprotein complex with RPA2 and SPATA22 proteins. MEIOB is expressed in the gonads and specifically in ovary and testis starting at the 14th weeks post fertilization. MEIOB is also expressed in a variety of tumors but not in other tissues other than testis and ovary. Because of its unique expression MEIOB is being examined as a possible anti-cancer autoimmune agent.
      References
      Product Information
      FormatSerum
      PresentationRabbit polyclonal serum with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-MEIOB Antibody is validated for use in Western Blotting and Immunoprecipitation and Immunocytochemistry for the detection of MEIOB.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      • Immunocytochemistry
      Application NotesImmunoprecipitation Analysis: A representative lot immunoprecipitated MEIOB in P18 testes (Luo, M., et al. (2013). Nature. DOI: 10.1038/ncomms3788 pg. 1-12).
      Immunocytochemistry Analysis: A representative lot detected MEIOB in mouse spermatocytes (Luo, M., et al. (2013). Nature. DOI: 10.1038/ncomms3788 pg. 1-12).
      Biological Information
      ImmunogenRecombinant protein corresponding to mouse MEIOB.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Meiob
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~50 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse testis tissue lysate.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected MEIOB in 10 µg of mouse testis tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      ABE1414 04055977051995

      Documentation

      Anti-MEIOB Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-MEIOB Antibody Certificates of Analysis

      TitleLot Number
      Anti-MEIOB - Q2467698 Q2467698
      Anti-MEIOB - 3600645 3600645
      Anti-MEIOB Polyclonal Antibody 3014959
      Anti-MEIOB Polyclonal Antibody 2935134

      References

      Reference overviewPub Med ID
      MEIOB exhibits single-stranded DNA-binding and exonuclease activities and is essential for meiotic recombination.
      Luo, M; Yang, F; Leu, NA; Landaiche, J; Handel, MA; Benavente, R; La Salle, S; Wang, PJ
      Nature communications  4  2788  2013

      Show Abstract       		24240703 24240703