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PC548T Anti-Porin (Ab-5) Rabbit pAb

Anti-Porin (Ab-5) Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
PC548T
  
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      Overview

      Replacement Information

      Key Specifications Table

      Host
      Rb
      Description
      Overview

      This product has been discontinued.





      Recognizes the approximate 31 kDa porin, a constituent of the outer membrane mitochondrial.
      Catalogue NumberPC548T
      Brand Family Calbiochem®
      Application Data
      Detection of rat porin by immunoblotting. Sample: Whole tissue extract from rat heart. Primary antibody: Anti-Porin (Ab-5) Rabbit pAb (Cat. No. PC548) (2 µg/ml). Detection: chemiluminescence
      References
      ReferencesCrompton, M., et al. 1999. Biochem. J. 341, 233.
      Yu, W.H., et al. 1995. J. Biol. Chem. 270, 13998.
      McEnry, M.W., et al. 1993. J. Biol. Chem. 268, 23289.
      Product Information
      FormLiquid
      FormulationIn PBS, 1 mg/ml BSA.
      Positive controlRat heart tissue extracts
      Preservative≤0.1% sodium azide
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Application NotesImmunoblotting (2 µg/ml)
      Application CommentsVDAC has been implicated in the formation of the mitochondrial permeability transition pore complex in apoptotic cells. Antibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogena synthetic peptide corresponding to amino acids 185-197 of human VDAC (voltage-dependent anion channel)
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      PC548T 0

      Documentation

      Anti-Porin (Ab-5) Rabbit pAb Certificates of Analysis

      TitleLot Number
      PC548T

      References

      Reference overview
      Crompton, M., et al. 1999. Biochem. J. 341, 233.
      Yu, W.H., et al. 1995. J. Biol. Chem. 270, 13998.
      McEnry, M.W., et al. 1993. J. Biol. Chem. 268, 23289.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-October-2007 RFH
      ApplicationImmunoblotting (2 µg/ml)
      Application Data
      Detection of rat porin by immunoblotting. Sample: Whole tissue extract from rat heart. Primary antibody: Anti-Porin (Ab-5) Rabbit pAb (Cat. No. PC548) (2 µg/ml). Detection: chemiluminescence
      DescriptionImmunoaffinity purified rabbit polyclonal antibody. Recognizes the ~31 kDa (VDAC) porin protein.
      BackgroundThe Voltage-Dependent Anion Channel (VDAC or mitochondrial Porin) is a constituent of the outer mitochondrial membrane. The VDAC protein is thought to form the major pores through which adenine nucleotides are transferred through the outer mitochondrial membrane. VDAC has also been implicated in the formation of the mitochondrial permeability transition pore complex in apoptotic cells. This complex, formed by VDAC, adenine nucleotide translocator (ANT), and cyclophilin D (CypD), is thought to allow the mitochondria to undergo metabolic uncoupling and irreversible morphologic changes that ultimately destroy the mitochondria during apoptosis. There are also strong indications that the VDAC-adenine nucleotide translocase-CyP-D complex can recruit a number of other proteins, including Bax, and that the complex is utilized in some capacity during apoptosis.
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide corresponding to amino acids 185-197 of human VDAC (voltage-dependent anion channel)
      IsotypeIgG
      Specieshuman, rat
      Positive controlRat heart tissue extracts
      FormLiquid
      FormulationIn PBS, 1 mg/ml BSA.
      Concentration Label Please refer to vial label for lot-specific concentration
      Preservative≤0.1% sodium azide
      CommentsVDAC has been implicated in the formation of the mitochondrial permeability transition pore complex in apoptotic cells. Antibody should be titrated for optimal results in individual systems.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesCrompton, M., et al. 1999. Biochem. J. 341, 233.
      Yu, W.H., et al. 1995. J. Biol. Chem. 270, 13998.
      McEnry, M.W., et al. 1993. J. Biol. Chem. 268, 23289.

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      Catalog Number Description  
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      PC548 Anti-Porin (Ab-5) (185-197) Rabbit pAb Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies