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MABE1033 Anti-SMARCB1 Antibody, clone 2C2

Anti-SMARCB1 Antibody, clone 2C2 is an antibody against SMARCB1 for use in Western Blotting and Immunocytochemistry.

Anti-SMARCB1 Antibody, clone 2C2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Nuclear Receptors Gene Symbol: SMARCB1, BAF47, INI1, SNF5L1
UniProt Number: Q12824
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MABE1033
100 µg  
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      Overview

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABE1033
      DescriptionAnti-SMARCB1 Antibody, clone 2C2
      Alternate Names
      • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
      • BRG1-associated factor 47
      • BAF47
      • Integrase interactor 1 protein
      • SNF5 homolog
      • hSNF5
      • SMARCB1
      Background InformationSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1), also known as BRG1-associated factor 47 (BAF47) or Integrase interactor 1 protein or SNF5 homolog (hSNF5), and encoded by the gene name SMARCB1 or BAF47, is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein has also been shown to bind to and enhance the DNA joining activity of HIV-1 integrase. It has been found to be a tumor suppressor, and the loss of SMARCB1 has been associated with malignant rhabdoid tumors. Tumor cells of synovial sarcoma seem to have a post transcriptional regulatory mechanism for SMARCB1.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-SMARCB1 Antibody, clone 2C2 is an antibody against SMARCB1 for use in Western Blotting and Immunocytochemistry.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected SMARCB1 in 10 µg of HEK293 cell lysate.
      Immunocytochemistry Analysis: A representative lot detected SMARCB1 in HeLa cells (Harada, A., et al. (2014). Mono. Antibodies in Immuno. and Immunotherapy. 33:49-51).
      Western Blotting Analysis: A representative lot detected SMARCB1 in HeLa cells (Harada, A., et al. (2014). Mono. Antibodies in Immuno. and Immunotherapy. 33:49-51).
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human SMARCB1.
      Clone2C2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SMARCB1
      • BAF47
      • INI1
      • SNF5L1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~ 45 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected SMARCB1 in 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      MABE1033 04055977135282

      Documentation

      Anti-SMARCB1 Antibody, clone 2C2 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-SMARCB1 Antibody, clone 2C2 Certificates of Analysis

      TitleLot Number
      Anti-SMARCB1, clone 2C2 -Q2550841 Q2550841

      References

      Reference overviewPub Med ID
      Monoclonal antibodies in immunodiagnosis and immunotherapy
      Harada, A; Hayashi, M; Kuniyoshi, Y; Semba, Y; Sugahara, S; Tachibana, T; Ohkawa, Y; Fujita, M
      Monoclonal antibodies in immunodiagnosis and immunotherapy  33  49-51  2014

      Show Abstract       		24555937 24555937

      Brochure

      Title
      NPI Flyer- Epigenetics and Nuclear Function Feature
      New Products - Antibodies, Small Molecule, Inhibitors

      Technical Info

      Title
      White Paper: Further considerations of antibody validation and usage.