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PC392 Anti-TRAIL Receptor-2 (Ab-1) Rabbit pAb

Anti-TRAIL Receptor-2 (Ab-1) Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-Death Receptor, Anti-APO2, Anti-DR5

PC392
  
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      Overview

      Replacement Information

      Key Specifications Table

      Host
      Rb
      Description
      Overview

      This product has been discontinued.





      Recognizes ~55-58 kDa TRAIL receptor-2 (DR5) in HeLa and K562 cells.
      Catalogue NumberPC392
      Brand Family Calbiochem®
      SynonymsAnti-Death Receptor, Anti-APO2, Anti-DR5
      Application Data
      Detection of human TRAIL receptor 2 by immunoblotting. Sample: Whole cell lysate (50 μg) from HeLa and K562 cells. Primary antibody: Anti-TRAIL Receptor-2 (DR5) (Ab-1) Rabbit pAb (Cat. No. PC392) (1:500). Detection: chemiluminescence.

      Detection of human TRAIL receptor-2 by immunocytochemistry. Sample: Formalin-fixed HeLa cells. Primary antibody: Anti-TRAIL Receptor-2 (Ab-1) Rabbit pAb (Cat. No. PC392) (5 µg/ml). Detection: chemiluminescence.
      References
      ReferencesChaudhary, P.M., et al. 1997. Immunity 7, 821.
      MacFarlane, M., et al. 1997. J. Biol. Chem. 272, 25417.
      Pan, G., et al. 1997. Science 277, 815.
      Screaton, G.R., et al. 1997. Curr. Biol. 7, 693.
      Sheridan, J.P., et al. 1997. Science 277, 818.
      Walczak, H., et al. 1997. EMBO. J. 16, 5386.
      Wu, G.S., et al. 1997. Nat. Genet. 17, 141.
      Product Information
      FormLiquid
      FormulationIn PBS, 0.05% BSA.
      Positive controlHeLa cells
      Preservative≤0.1% sodium azide
      Applications
      Application ReferencesParaffin Sections Spierings DCJ, et al. 2003. Clin Cancer Res. 9,3397.
      Key Applications Immunoblotting (Western Blotting)
      Paraffin Sections
      Application NotesImmunoblotting (1:500-1:1000)
      Paraffin Sections (5 µg/ml, see application references)
      Application CommentsAntibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogena synthetic peptide (KWVNKTGRDASVHTLLDALE) corresponding to amino acids 388-407 of human TRAIL receptor-2 (DR5) precursor
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Highly Toxic
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      PC392 0

      Documentation

      Anti-TRAIL Receptor-2 (Ab-1) Rabbit pAb SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-TRAIL Receptor-2 (Ab-1) Rabbit pAb Certificates of Analysis

      TitleLot Number
      PC392

      References

      Reference overview
      Chaudhary, P.M., et al. 1997. Immunity 7, 821.
      MacFarlane, M., et al. 1997. J. Biol. Chem. 272, 25417.
      Pan, G., et al. 1997. Science 277, 815.
      Screaton, G.R., et al. 1997. Curr. Biol. 7, 693.
      Sheridan, J.P., et al. 1997. Science 277, 818.
      Walczak, H., et al. 1997. EMBO. J. 16, 5386.
      Wu, G.S., et al. 1997. Nat. Genet. 17, 141.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-April-2008 JSW
      SynonymsAnti-Death Receptor, Anti-APO2, Anti-DR5
      ApplicationImmunoblotting (1:500-1:1000)
      Paraffin Sections (5 µg/ml, see application references)
      Application Data
      Detection of human TRAIL receptor 2 by immunoblotting. Sample: Whole cell lysate (50 μg) from HeLa and K562 cells. Primary antibody: Anti-TRAIL Receptor-2 (DR5) (Ab-1) Rabbit pAb (Cat. No. PC392) (1:500). Detection: chemiluminescence.

      Detection of human TRAIL receptor-2 by immunocytochemistry. Sample: Formalin-fixed HeLa cells. Primary antibody: Anti-TRAIL Receptor-2 (Ab-1) Rabbit pAb (Cat. No. PC392) (5 µg/ml). Detection: chemiluminescence.
      DescriptionProtein G purified rabbit polyclonal antibody. Recognizes the ~55-58 kDa TRAIL receptor-2 protein.
      BackgroundApoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-κB.
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide (KWVNKTGRDASVHTLLDALE) corresponding to amino acids 388-407 of human TRAIL receptor-2 (DR5) precursor
      IsotypeIgG
      Specieshuman
      Positive controlHeLa cells
      FormLiquid
      FormulationIn PBS, 0.05% BSA.
      Concentration Label Please refer to vial label for lot-specific concentration
      Preservative≤0.1% sodium azide
      CommentsAntibody should be titrated for optimal results in individual systems.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Highly Toxic
      ReferencesChaudhary, P.M., et al. 1997. Immunity 7, 821.
      MacFarlane, M., et al. 1997. J. Biol. Chem. 272, 25417.
      Pan, G., et al. 1997. Science 277, 815.
      Screaton, G.R., et al. 1997. Curr. Biol. 7, 693.
      Sheridan, J.P., et al. 1997. Science 277, 818.
      Walczak, H., et al. 1997. EMBO. J. 16, 5386.
      Wu, G.S., et al. 1997. Nat. Genet. 17, 141.
      Application referencesParaffin Sections Spierings DCJ, et al. 2003. Clin Cancer Res. 9,3397.