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MABE201 Anti-UTX/KDM6A Antibody, clone 16F9.1

This Anti-UTX/KDM6A Antibody, clone 16F9.1 is validated for use in Western Blotting for the detection of UTX/KDM6A.

Anti-UTX/KDM6A Antibody, clone 16F9.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Nuclear Receptors Gene Symbol: KDM6A, UTX UniProt Number: O15550
MABE201
100 μg  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABE201
      DescriptionAnti-UTX/KDM6A Antibody, clone 16F9.1
      Alternate Names
      • Lysine-specific demethylase 6A
      • UTX/KDM6A
      • Histone demethylase UTX
      • Ubiquitously-transcribed TPR protein on the X chromosome
      • Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein
      Background InformationLysine-specific demethylase 6A (UniProt O15550; also known as Histone demethylase UTX, Ubiquitously transcribed tetratricopeptide repeat protein X-linked, Ubiquitously-transcribed TPR gene on the X chromosome, Ubiquitously transcribed X chromosome tetratricopeptide repeat protein) is encoded by the KDM6A (also known as bA386N14.2, KABUK2, UTX) gene (Gene ID 7403) in human. Histone lysine demethylases are divided into the flavin adenine dinucleotide-/FAD-dependent amine oxidases that target mono-, di-, but not tri-, methylated histone lysine residues and the Jumonji C/JmjC domain-containing enzymes that target specific mono-, di- and tri-methylated histone lysine residues. The JmjC domain enzymes rely on α-ketoglutarate (α-KG), Fe(II), and molecular oxygen as cofactors in the demethylation reaction. KDM6A/UTX, KDM6B/JMJD3, and UTY constitute the KDM6 subfamily of JmjC domain-containing histome demethylases. KDM6A/UTX and KDM6B/JMJD3 target H3K27me3 and H3K27me2, whereas UTY display little catalytic activity.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-UTX/KDM6A Antibody, clone 16F9.1 is validated for use in Western Blotting for the detection of UTX/KDM6A.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the Internal (N-terminal half) of human UTX/KDM6A.
      EpitopeInternal (N-terminal half)
      Clone16F9.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KDM6A
      • UTX
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~155 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa nuclear extract.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected UTX/KDM6A in 10 µg of HeLa nuclear extract.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      MABE201 04055977297386

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies