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196000 Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem

This product can no longer be ordered through emdmillipore.com. Please refer to (Cat. No. 196000) on sigmaaldrich.com.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: vacuolar type H+ ATPase
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196000
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
88899-55-2C₃₅H₅₈O₉

Pricing & Availability

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196000-10UG
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      		 Plastic ampoule 10 μg
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      196000-1SET
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          		 Glass bottle 1 set
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          Description
          OverviewA macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). The InSolution™ format with a purity of ≥97% by HPLC in 90% DMSO is also available (Cat. No. 508409).
          Note: 1 set = 3 x 10 µg
          Catalogue Number196000
          Brand Family Calbiochem®
          References
          ReferencesSinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
          Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
          Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
          Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
          Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
          Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
          Drose, S., et al. 1993. Biochemistry 32, 3902.
          Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
          Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.
          Product Information
          CAS number88899-55-2
          FormWhite solid
          Hill FormulaC₃₅H₅₈O₉
          Chemical formulaC₃₅H₅₈O₉
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetvacuolar type H+ ATPase
          Primary Target IC<sub>50</sub>500 pM
          Purity≥90% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 22-26-36

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 year at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalog Number GTIN
          196000-10UG 04055977206456
          196000-1SET 04055977206449

          Documentation

          Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem Certificates of Analysis

          TitleLot Number
          196000

          References

          Reference overview
          Sinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
          Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
          Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
          Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
          Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
          Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
          Drose, S., et al. 1993. Biochemistry 32, 3902.
          Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
          Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.

          Technical Info

          Title
          Molecular Biology Grade Reagents
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-February-2010 JSW
          DescriptionA macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 0.5 nM) and is a valuable tool for distinguishing among different types of ATPases. Reported to selectivity inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). Blocks lysosomal cholesterol trafficking in macrophages. Known to interfere with pH regulation in brain cells. Inhibits bone resorption both in vivo and in vitro. Has been shown to exhibit cytotoxic effects on a number of cell lines in a cell viability assay.
          FormWhite solid
          CAS number88899-55-2
          Chemical formulaC₃₅H₅₈O₉
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO (100 µM) or Ethanol
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 year at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesSinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
          Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
          Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
          Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
          Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
          Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
          Drose, S., et al. 1993. Biochemistry 32, 3902.
          Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
          Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.