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197330 Bcl-2 Inhibitor - CAS 383860-03-5 - Calbiochem

The Bcl-2 Inhibitor, also referenced under CAS 383860-03-5, controls the biological activity of Bcl-2. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2,9-Dimethoxy-11,12-dihydrodibenzo[c,g][1,2]-diazocine 5,6-dioxide (A) and 5,5ʹ-Dimethoxy-2,2ʹ-dinitrosobenzyl (B)

Primary Target: Bcl-2
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197330
  
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      383860-03-5C₁₆H₁₆N₂O₄
      Description
      Overview

      This product has been discontinued.



      Contains mixture of two tautomers (A and B). A potent, cell-permeable, Bcl-2 inhibitor that competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-xL in vitro (IC50 = 10 µM and 7 µM, respectively). Reduces cell viability and growth in the HL-60 cell line with high Bcl-2 expression (IC50 = 4 µM). Also induces apoptosis in a dose-dependent manner in cancer cells exhibiting high Bcl-2 expression with little effect on cancer cells with low Bcl-2 expression.
      Catalogue Number197330
      Brand Family Calbiochem®
      Synonyms2,9-Dimethoxy-11,12-dihydrodibenzo[c,g][1,2]-diazocine 5,6-dioxide (A) and 5,5ʹ-Dimethoxy-2,2ʹ-dinitrosobenzyl (B)
      References
      ReferencesEnyedy, I.J., et al. 2001. J. Med. Chem. 44, 4313.
      Product Information
      CAS number383860-03-5
      FormGreen solid
      Hill FormulaC₁₆H₁₆N₂O₄
      Chemical formulaC₁₆H₁₆N₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetBcl-2
      Primary Target IC<sub>50</sub>10 µM and 7 µM for competing with Bak BH3 peptide for binding to Bcl-2 and Bcl-xL in vitro, respectively; 4 µM for reducing cell viability and growth in the HL-60 cell line with high Bcl-2 expression
      Purity≥97% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze under inert gas (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      197330 0

      Documentation

      Bcl-2 Inhibitor - CAS 383860-03-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Bcl-2 Inhibitor - CAS 383860-03-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      197330

      References

      Reference overview
      Enyedy, I.J., et al. 2001. J. Med. Chem. 44, 4313.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      Synonyms2,9-Dimethoxy-11,12-dihydrodibenzo[c,g][1,2]-diazocine 5,6-dioxide (A) and 5,5ʹ-Dimethoxy-2,2ʹ-dinitrosobenzyl (B)
      DescriptionContains a mixture of two tautomers (A and B). Potent, cell-permeable Bcl-2 inhibitor that competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-XL in vitro (IC50 = 10 µM and 7 µM, respectively). Shown to reduce cell viability (IC50 = 10 µM) and growth in HL60 cells with high levels of Bcl-2 expression (IC50 = 4 µM). Induces apoptosis in a dose-dependent manner in cancer cells expressing high levels of Bcl-2, but has little or no effect on cells that express low levels of Bcl-2.
      FormGreen solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number383860-03-5
      Chemical formulaC₁₆H₁₆N₂O₄
      Structure formulaStructure formula
      Purity≥97% by TLC
      SolubilityDMSO (2.5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze under inert gas (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesEnyedy, I.J., et al. 2001. J. Med. Chem. 44, 4313.