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217699 Cdk1 Inhibitor IV, RO-3306 - Calbiochem

Overview

Key Specifications Table

Empirical Formula
C₁₈H₁₃N₃OS₂

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217699-5MG
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      Glass bottle 5 mg
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      Description
      OverviewA cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki ≥ 2 µM). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. Also available as a 10 mM solution in DMSO (Cat. No. 217721).
      Catalogue Number217699
      Brand Family Calbiochem®
      References
      ReferencesVassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660.
      Product Information
      ATP CompetitiveY
      FormBrown solid
      Hill FormulaC₁₈H₁₃N₃OS₂
      Chemical formulaC₁₈H₁₃N₃OS₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetCdk1
      Primary Target K<sub>i</sub>35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalog Number GTIN
      217699-5MG 04055977202342