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HTS007M ChemiSCREEN™ CCR2B Membrane Preparation

Human CCR2B GPCR membrane prepation for Radioligand binding Assays.

Host Cell: Chem-1 Uni Prot Number: P41597 Entrez Gene Number: NM_000647.4, NM_000648.2
HTS007M
200 assays  
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      Overview

      Replacement Information

      Key Specifications Table

      SpeciesHost CellsProtein Target
      Human Chem-1CCR2B
      Description
      Catalogue NumberHTS007M
      Brand Family Chemicon®
      Trade Name
      • ChemiScreen
      • Chemicon
      DescriptionChemiSCREEN™ CCR2B Membrane Preparation
      References
      Product Information
      FormatMembranes
      PresentationLiquid in packaging buffer: 50 mM Tris pH 7.4, 10% glycerol and 1% BSA with no preservatives.
      Packaging method: Membrane protein was adjusted to 1 mg/ml in 1 ml packaging buffer, rapidly frozen, and stored at -80°C.
      Quality LevelMQ100
      Applications
      ApplicationHuman CCR2B GPCR membrane prepation for Radioligand binding Assays.
      Key Applications
      • Radioligand binding assay
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.
      Gene Symbol
      • CCR2
      • CC-CKR-2
      • CCR2A
      • CCR-2
      • CKR2
      • CKR2A
      • MCP-1-R
      • CCR2B
      • CMKBR2
      • CD192
      • MCP-1
      • CKR2B
      GPCR ClassA
      Host CellsChem-1
      Protein TargetCCR2B
      Target Sub-FamilyChemokine
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P41597 # Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
      SIZE: 374 amino acids; 41915 Da
      SUBUNIT: Binds to HIV-1 Tat.
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      PTM: N-glycosylated.
      SIMILARITY: SwissProt: P41597 ## Belongs to the G-protein coupled receptor 1 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size200 assays
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      HTS007M 04053252472664

      Documentation

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      Life Science Research > Proteins and Enzymes > GPCR Membrane Preparations