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230752 Chromomycin A₃ - CAS 7059-24-7 - Calbiochem

Antitumor antibiotic that inhibits RNA synthesis. A cell-permeable fluorescent dye that can be used with Bisbenzimide H 33258 to distinguish chromosomes by their total DNA content and DNA base composition.

Chromomycin A₃ - CAS 7059-24-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Toyomycin

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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      7059-24-7C₅₇H₈₂O₂₆
      Description
      OverviewAntitumor antibiotic that inhibits RNA synthesis. A cell-permeable fluorescent dye that can be used with Bisbenzimide H 33258 (Cat. No. 382061) to distinguish chromosomes by their total DNA content and DNA base composition. Reversibly interacts with DNA in the presence of Mg2+. Binds to G:C pairs of helical DNA but does not intercalate.
      Catalogue Number230752
      Brand Family Calbiochem®
      SynonymsToyomycin
      References
      ReferencesAich, P., et al. 1992. Biochemistry 31, 2988.
      Saccone, S., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 4913.
      Van Dilla, M.A., et al. 1983. Science 220, 620.
      Mizuno, K. 1963. J. Antibiot. 16, 22.
      Product Information
      CAS number7059-24-7
      FormYellow solid
      Hill FormulaC₅₇H₈₂O₂₆
      Chemical formulaC₅₇H₈₂O₂₆
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥90% by HPLC
      Physicochemical Information
      Emission max.
      Excitation max.
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSGB7875000
      Safety Information
      R PhraseR: 26/27/28-61

      Very toxic by inhalation, in contact with skin and if swallowed.
      May cause harm to the unborn child.
      S PhraseS: 26-36/37/39-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing recosntitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      230752 0

      Documentation

      Chromomycin A₃ - CAS 7059-24-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Chromomycin A₃ - CAS 7059-24-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      230752

      References

      Reference overview
      Aich, P., et al. 1992. Biochemistry 31, 2988.
      Saccone, S., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 4913.
      Van Dilla, M.A., et al. 1983. Science 220, 620.
      Mizuno, K. 1963. J. Antibiot. 16, 22.

      Brochure

      Title
      Antibiotics Profiler
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-April-2008 RFH
      SynonymsToyomycin
      DescriptionAntibiotic that inhibits RNA synthesis by way of DNA-dependent RNA polymerase. Fluorescent dye that can be used in conjunction with Bisbenzimide H33258 (Cat. No. 382061) to distinguish chromosomes by their total DNA concentration and their DNA base composition. Binds to G:C pairs of helical DNA (Mg2+ required) but does not intercalate the A:T pairs, which preferentially bind Bisbenzimide H33258.
      FormYellow solid
      CAS number7059-24-7
      RTECSGB7875000
      Chemical formulaC₅₇H₈₂O₂₆
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityEthanol (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing recosntitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 2238
      ReferencesAich, P., et al. 1992. Biochemistry 31, 2988.
      Saccone, S., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 4913.
      Van Dilla, M.A., et al. 1983. Science 220, 620.
      Mizuno, K. 1963. J. Antibiot. 16, 22.