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14-657M DAPK2 Protein, active, 250 µg

Active, N-terminal GST-tagged, recombinant, human, full length DAPK2, for use in Kinase Assays.

14-657M
250 µg  Also available in 10 μg size (cat#14-657) and in bulk (cat# 14-657-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-657M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionDAPK2 Protein, active, 250 µg
      OverviewN-terminal GST-tagged, recombinant, human, full length DAPK2
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, N-terminal GST-tagged, recombinant, human, full length DAPK2, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed by baculovirus in Sf21 cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites.
      Gene Symbol
      • DAPK2
      • DRP-1
      • MGC119312
      Protein TargetDAPK2
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyCAMK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9UIK4 # Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis.
      COFACTOR: Magnesium.
      SIZE: 370 amino acids; 42898 Da
      SUBUNIT: Homodimer. Homodimerization is required for apoptotic function and is inhibited by autophosphorylation at Ser-318.
      SUBCELLULAR LOCATION: Cytoplasm.
      TISSUE SPECIFICITY: Ubiquitously expressed in all tissue types examined. High levels in heart, lung and skeletal muscle.
      SIMILARITY: SwissProt: Q9UIK4 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. & Contains 1 protein kinase domain.
      Molecular Weight70.6kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of ZIPtide (Catalog # 12-545)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C from date of shipment
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-657) and in bulk (cat# 14-657-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      14-657M 04053252272110

      Documentation

      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      14-657 DAPK2 Protein, active, 10 µg Show Pricing & Availability

      Product Families

      Kinase & Phosphatase Products

      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Categories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases