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322338 Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem

The Dvl-PDZ Domain Inhibitor II, also referenced under CAS 294891-81-9, controls the biological activity of Dvl-PDZ. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Wnt Pathway Inhibitor IV, 2-((3-(2-Phenylacetyl)amino)benzoyl)amino)benzoic acid, 3289-8625

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322338
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
294891-81-9C₂₂H₁₈N₂O₄

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      Description
      OverviewA cell-permeable amidobenzanilide compound that disrupts Fz-Dvl (frizzled-dishevelled) interaction by targeting the PDZ domain (Kd = 10.6 µM) of Dvl, blocking Wnt3a-induced (10 ng/ml) transcription activity (~50% inhibition at 3 µM in 293 cell SuperTopflash reporter assays) and suppressing the Wnt pathway-dependent growth of prostate cancer PC-3 cells (by 16% in 72 h at ≥50 µM; IC50 = 12.5 µM). Shown to effectively prevent Wnt3A mRNA injection-induced xenopus embryo deformation (effective conc. = 25 µM) and suppress Wnt pathway-mediated apoptosis of the hyaloid vescular endothelial cells in the mouse eyes via vitreous injection (144 fmol/120 nl/eye) in vivo.
      Catalogue Number322338
      Brand Family Calbiochem®
      SynonymsWnt Pathway Inhibitor IV, 2-((3-(2-Phenylacetyl)amino)benzoyl)amino)benzoic acid, 3289-8625
      References
      ReferencesGrandy, D., et al. 2009. J. Biol. Chem. 284, 16256.
      Product Information
      CAS number294891-81-9
      FormWhite solid
      Hill FormulaC₂₂H₁₈N₂O₄
      Chemical formulaC₂₂H₁₈N₂O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      322338-10MG 04055977216356

      Documentation

      Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      322338

      References

      Reference overview
      Grandy, D., et al. 2009. J. Biol. Chem. 284, 16256.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2011 RFH
      SynonymsWnt Pathway Inhibitor IV, 2-((3-(2-Phenylacetyl)amino)benzoyl)amino)benzoic acid, 3289-8625
      DescriptionA cell-permeable amidobenzanilide compound that disrupts Fz-Dvl (frizzled-dishevelled) interaction by targeting the PDZ domain (Kd = 10.6 µM) of Dvl, blocking Wnt3a-induced (10 ng/ml) transcription activity (~50% inhibition at 3 µM in 293 cell SuperTopflash reporter assays) and suppressing the Wnt pathway-dependent growth of prostate cancer PC-3 cells (by 16% in 72 h at ≥50 µM; IC50 = 12.5 µM). Shown to effectively prevent Wnt3A mRNA injection-induced xenopus embryo deformation (effective conc. = 25 µM) and suppress Wnt pathway-mediated apoptosis of the hyaloid vescular endothelial cells in the mouse eyes via vitreous injection (144 fmol/120 nl/eye) in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number294891-81-9
      Chemical formulaC₂₂H₁₈N₂O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesGrandy, D., et al. 2009. J. Biol. Chem. 284, 16256.