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346110 Glucocorticoid Receptor Modulator, CpdA - CAS 14593-25-0 - Calbiochem

A cell-permeable aziridine precursor that acts as a nonsteroidal glucocorticoid receptor ligand with a binding affinity that is 4-fold higher than that of Dexamethasone.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-((4-Acetoxyphenyl)-2-chloro-N-methyl)ethylammonium chloride

Primary Target: A nonsteroidal glucocorticoid receptor (GR, Cat. No. 346100) ligand
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      14593-25-0C₁₁H₁₄ClNO₂ • HCl
      Description
      Overview

      This product has been discontinued.



      A cell-permeable aziridine precursor that acts as a nonsteroidal glucocorticoid receptor (GR, Cat. No. 346100) ligand with a binding affinity that is 4-fold higher than that of Dexamethasone (DEX, Cat. No. 265005). Induces GR nuclear translocation and selectively activates GR-mediated transrepression of the NF-κB-dependent production of pro-inflammatory cytokines. Unlike DEX, CpdA exhibits no effect on GRE- (glucocorticoid response element) driven gene expression. Reported to be as effective as DEX in suppressing acute inflammation in mice in vivo without the hyperglycemic side effect that is commonly associated with DEX.
      Catalogue Number346110
      Brand Family Calbiochem®
      Synonyms2-((4-Acetoxyphenyl)-2-chloro-N-methyl)ethylammonium chloride
      References
      ReferencesDe Bosscher, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 15827.
      Product Information
      CAS number14593-25-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₁H₁₄ClNO₂ • HCl
      Chemical formulaC₁₁H₁₄ClNO₂ • HCl
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetA nonsteroidal glucocorticoid receptor (GR, Cat. No. 346100) ligand
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Ethanol stock solutions are stable for up to 1 month at -70°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      346110 0

      Documentation

      Glucocorticoid Receptor Modulator, CpdA - CAS 14593-25-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Glucocorticoid Receptor Modulator, CpdA - CAS 14593-25-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      346110

      References

      Reference overview
      De Bosscher, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 15827.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-April-2011 RFH
      Synonyms2-((4-Acetoxyphenyl)-2-chloro-N-methyl)ethylammonium chloride
      DescriptionA cell-permeable aziridine precursor that acts as a nonsteroidal glucocorticoid receptor (GR, Cat. No. 346100) ligand with a binding affinity that is 4-fold higher than that of Dexamethasone (DEX, Cat. No. 265005). Induces GR nuclear translocation and selectively activates GR-mediated transrepression of the NF-κB-dependent production of pro-inflammatory cytokines. Unlike DEX, CpdA exhibits no effect on GRE- (glucocorticoid response element) driven gene expression. Reported to be as effective as DEX in suppressing acute inflammation in mice in vivo without the hyperglycemic side effect that is commonly associated with DEX.
      FormWhite solid
      CAS number14593-25-0
      Chemical formulaC₁₁H₁₄ClNO₂ • HCl
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityEthanol (anhydrous, 5 mg/ml), DMSO (10 mg/ml), or H₂O (1 mg/ml)
      Storage Protect from moisture
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Ethanol stock solutions are stable for up to 1 month at -70°C.
      Toxicity Standard Handling
      ReferencesDe Bosscher, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 15827.