345862 Sigma-AldrichGolgicide A - CAS 1139889-93-2 - Calbiochem
A cell-permeable quinoline compound that selectively targets ArfGEF GBF1, but not BIG1/2, and attenuates GBF1-mediated cellular vesicle traffickings in a reversible manner.
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Synonyms: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline, GCA
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 1139889-93-2 | C₁₇H₁₄F₂N₂ |
Pricing & Availability
| Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 345862-10MG |
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Plastic ampoule | 10 mg |
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| Description | |
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| Overview | A cell-permeable quinoline compound that selectively targets ArfGEF GBF1, but not BIG1/2, and attenuates GBF1-mediated cellular vesicle traffickings in a reversible manner. Phenotypic comparisons in Vero (African Green Monkey Kidney epithelial) cultures reveal that selective blockage of GBF1 function by GCA (10 µM) or by FGB1-E794K dominant-inactive expression affects medial- and cis-Golgi similarly to that seen with BFA (Cat. No. 203729), however, the non-GBF1-specific BFA (10 µg/ml or 35.6 µM) causes additional GBF1-independent morphologic effects on TGN, notably the rapid dispersal of Golgi-associated coat proteins AP-1 and GGA3, which are not seen with GCA treatment. Endocytic/retrograde transport studies using GCA establishes that GBF1 function is not required for the transport of bacterial toxins to the endosomes, however the retrograde transport of StxB (shiga toxin B subunit) from endosomes to TGN and Golgi is GBF1-dependent (100% inhibition of StxB sulfation at 10 µM), accounting for GCA's (10 µM) ability to completely prevent Vera cells from Stx-induced (up to 100 ng/ml) inhibition of cellular protein synthesis. |
| Catalogue Number | 345862 |
| Brand Family | Calbiochem® |
| Synonyms | 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline, GCA |
| References | |
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| References | Saenz, J.B., et al. 2009. Nat. Chem. Biol. 5, 157. |
| Product Information | |
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| CAS number | 1139889-93-2 |
| Form | Off-white solid |
| Hill Formula | C₁₇H₁₄F₂N₂ |
| Chemical formula | C₁₇H₁₄F₂N₂ |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥95% by HPLC |
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| Safety Information according to GHS |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 345862-10MG | 04055977214420 |
Documentation
Golgicide A - CAS 1139889-93-2 - Calbiochem SDS
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Golgicide A - CAS 1139889-93-2 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 345862 |
References
| Reference overview |
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| Saenz, J.B., et al. 2009. Nat. Chem. Biol. 5, 157. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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