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368043 Granzyme B, Human, Recombinant, E. coli

Granzyme B, Human, Recombinant, E. coli, is a serine protease used by activated cytotoxic T cells to induce apoptosis. Induces cell perforation and initiates proteolysis leading to cell death.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: GzmB

368043
  
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      Overview

      Replacement Information
      Description
      OverviewRecombinant, human granzyme B expressed in E. coli. Granzyme B (GzmB) is a serine protease that is used by activated cytotoxic T lymphocytes (CTL) to induce target cell apoptosis. It is involved in the perforation of target cells and initiation of proteolysis that leads the cell into the apoptosis pathway.
      Catalogue Number368043
      Brand Family Calbiochem®
      SynonymsGzmB
      References
      ReferencesWilharm, E., et al. 1999. J. Biol. Chem. 274, 27331.
      Harris, J. L., et al. 1998. J. Biol. Chem. 273, 27364.
      Product Information
      Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1 nmol Ac-IEPD-<i>p</i>NA per min 25° C, pH 8.0.
      EC number3.4.21.79
      FormLiquid
      FormulationIn TBS, 50% glycerol.
      Applications
      ApplicationGranzyme B, Human, Recombinant, E. coli, is a serine protease used by activated cytotoxic T cells to induce apoptosis. Induces cell perforation and initiates proteolysis leading to cell death.
      Biological Information
      Specific Activity≥7.0 units/µg protein
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      368043 0

      Documentation

      Granzyme B, Human, Recombinant, E. coli SDS

      Title

      Safety Data Sheet (SDS) 

      Granzyme B, Human, Recombinant, E. coli Certificates of Analysis

      TitleLot Number
      368043

      References

      Reference overview
      Wilharm, E., et al. 1999. J. Biol. Chem. 274, 27331.
      Harris, J. L., et al. 1998. J. Biol. Chem. 273, 27364.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-January-2011 RFH
      SynonymsGzmB
      DescriptionRecombinant, human granzyme B expressed in E. coli. Granzyme B (GzmB) is a serine protease that is involved in cytotoxic T lymphocyte-induced (CTL) cell death. It is reported to participate in the perforation of target cells and initiation of proteolysis that leads apoptosis. Similar to caspases, granzyme B preferentially cleaves substrate proteins with aspartic acid in the P1 position.
      FormLiquid
      FormulationIn TBS, 50% glycerol.
      EC number3.4.21.79
      Specific activity≥7.0 units/µg protein
      Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze 1 nmol Ac-IEPD-pNA per min 25° C, pH 8.0.
      Storage Avoid freeze/thaw
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesWilharm, E., et al. 1999. J. Biol. Chem. 274, 27331.
      Harris, J. L., et al. 1998. J. Biol. Chem. 273, 27364.