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375670 Herbimycin A, Streptomyces sp. - CAS 70563-58-5 - Calbiochem

A potent and cell-permeable protein tyrosine kinase inhibitor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: P60v-src
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375670
  
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      70563-58-5C₃₀H₄₂N₂O₉
      Description
      OverviewA potent and cell-permeable protein tyrosine kinase inhibitor. Inhibits p60v-src (IC50 = 12 µM) and PDGF-induced phospholipase D activation (IC50 = 8 µg/ml). Reported to inhibit c-Src related bone resorption (IC50 = 70 nM). Inhibits angiogenesis in chick chorioallantoic membrane. Also shown to inhibit anti-CD3 monoclonal antibody-induced apoptosis of thymocytes.
      Catalogue Number375670
      Brand Family Calbiochem®
      References
      ReferencesFan, T.-P., et al. 1995. Trends Pharmacol. Sci. 16, 57.
      Kim, B.Y. 1995. Biochem. Biophys. Res. Commun. 212, 1061.
      Migita, K., et al. 1994. J. Immunol. 153, 3457.
      Okabe, M., et al. 1994. Leuk. Res. 18, 867.
      Fukazawa, H., et al. 1991. Biochem. Pharmacol. 42, 1661.
      Obinata, A., et al. 1991. Exp. Cell Res. 193, 36.
      Park, D.J., et al. 1991. J. Biol. Chem. 266, 24237.
      Weinstein, S.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4148.
      Oikawa, T., et al. 1989. Cancer Lett. 48, 157.
      Uehara, Y., et al. 1989. Biochem. Biophys. Res. Commun. 163, 803.
      Uehara, Y., et al. 1988. Virology 164, 294.
      Omura, S., et al. 1979. J. Antibiotics 32, 255.
      Product Information
      CAS number70563-58-5
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₃₀H₄₂N₂O₉
      Chemical formulaC₃₀H₄₂N₂O₉
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetP60v-src
      Primary Target IC<sub>50</sub>12 µM against P60v-src
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSLX8930000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      375670 0

      Documentation

      Herbimycin A, Streptomyces sp. - CAS 70563-58-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Herbimycin A, Streptomyces sp. - CAS 70563-58-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      375670

      References

      Reference overview
      Fan, T.-P., et al. 1995. Trends Pharmacol. Sci. 16, 57.
      Kim, B.Y. 1995. Biochem. Biophys. Res. Commun. 212, 1061.
      Migita, K., et al. 1994. J. Immunol. 153, 3457.
      Okabe, M., et al. 1994. Leuk. Res. 18, 867.
      Fukazawa, H., et al. 1991. Biochem. Pharmacol. 42, 1661.
      Obinata, A., et al. 1991. Exp. Cell Res. 193, 36.
      Park, D.J., et al. 1991. J. Biol. Chem. 266, 24237.
      Weinstein, S.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4148.
      Oikawa, T., et al. 1989. Cancer Lett. 48, 157.
      Uehara, Y., et al. 1989. Biochem. Biophys. Res. Commun. 163, 803.
      Uehara, Y., et al. 1988. Virology 164, 294.
      Omura, S., et al. 1979. J. Antibiotics 32, 255.

      Citations

      Title
    • Satoshi Fukumoto, et al. (2006) Laminin 5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. Journal of Biological Chemistry 281, 5008-5016.
    • Dylan T. Jones, et al. (2004) Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs. Blood 103, 1855-1861.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-July-2008 RFH
      DescriptionA cell-permeable, potent inhibitor of protein tyrosine kinases. Inhibits p60v-src (IC50 = 12 µM) autophosphorylation. Irreversibly binds to the sulfhydryl groups of the kinase. Dose-dependently inhibits PDGF-induced phospholipase D activation (IC50 = 8 µg/ml). Also, reported to inhibit c-src related bone resorption (IC50 = 70 nM). Inhibits angiogenesis in chick chorioallantoic membrane and blocks anti-CD3 monoclonal antibody-induced apoptosis of thymocytes. Several mammalian cell lines transformed with tyrosine kinase oncogenes (src, abl, fps, ros, yes, erbB) show reversion from the transformed to the normal phenotype after treatment with herbimycin A.
      FormYellow solid
      CAS number70563-58-5
      RTECSLX8930000
      Chemical formulaC₃₀H₄₂N₂O₉
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (1 mg/ml). Further dilute with H₂O or aqueous buffers just prior to use.
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesFan, T.-P., et al. 1995. Trends Pharmacol. Sci. 16, 57.
      Kim, B.Y. 1995. Biochem. Biophys. Res. Commun. 212, 1061.
      Migita, K., et al. 1994. J. Immunol. 153, 3457.
      Okabe, M., et al. 1994. Leuk. Res. 18, 867.
      Fukazawa, H., et al. 1991. Biochem. Pharmacol. 42, 1661.
      Obinata, A., et al. 1991. Exp. Cell Res. 193, 36.
      Park, D.J., et al. 1991. J. Biol. Chem. 266, 24237.
      Weinstein, S.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4148.
      Oikawa, T., et al. 1989. Cancer Lett. 48, 157.
      Uehara, Y., et al. 1989. Biochem. Biophys. Res. Commun. 163, 803.
      Uehara, Y., et al. 1988. Virology 164, 294.
      Omura, S., et al. 1979. J. Antibiotics 32, 255.
      Citation
    • Satoshi Fukumoto, et al. (2006) Laminin 5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. Journal of Biological Chemistry 281, 5008-5016.
    • Dylan T. Jones, et al. (2004) Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs. Blood 103, 1855-1861.
      		•