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400046 Hydroxyurea - CAS 127-07-1 - Calbiochem

Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase.

Hydroxyurea - CAS 127-07-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ribonucleotide Reductase Inhibitor I, RNR Inhibitor I

Primary Target: Inhibiting ribonucleotide reductase
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400046
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
127-07-1CH₄N₂O₂

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      Description
      OverviewAnti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents.
      Catalogue Number400046
      Brand Family Calbiochem®
      SynonymsRibonucleotide Reductase Inhibitor I, RNR Inhibitor I
      References
      ReferencesLeyden, D., et al. 2000. Anticancer Res. 20, 133.
      Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
      Anand, S., et al. 1995. Cancer Lett. 88, 101.
      Product Information
      CAS number127-07-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaCH₄N₂O₂
      Chemical formulaCH₄N₂O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetInhibiting ribonucleotide reductase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSYT4900000
      Safety Information
      R PhraseR: 46-61

      May cause heritable genetic damage.
      May cause harm to the unborn child.
      S PhraseS: 45-53

      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Avoid exposure - obtain special instructions before use.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      400046-5GM 04055977212129

      Documentation

      Hydroxyurea - CAS 127-07-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Hydroxyurea - CAS 127-07-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      400046

      References

      Reference overview
      Leyden, D., et al. 2000. Anticancer Res. 20, 133.
      Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
      Anand, S., et al. 1995. Cancer Lett. 88, 101.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-November-2018 JSW
      SynonymsRibonucleotide Reductase Inhibitor I, RNR Inhibitor I
      DescriptionAntineoplastic agent. Blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes.
      FormWhite solid
      CAS number127-07-1
      RTECSYT4900000
      Chemical formulaCH₄N₂O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (5 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 4848
      ReferencesLeyden, D., et al. 2000. Anticancer Res. 20, 133.
      Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
      Anand, S., et al. 1995. Cancer Lett. 88, 101.