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401011 Hypothemycin - CAS 76958-67-3 - Calbiochem

A cell-permeable cis-enone resorlic acid lactone (RAL) and (5Z)-7-Oxozeaenol analog that inhibits several kinases via an initial affinity binding to the ATP pocket.

Hypothemycin - CAS 76958-67-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NSC 354462

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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      76958-67-3C₁₉H₂₂O₈
      Description
      OverviewA cell-permeable cis-enone resorlic acid lactone (RAL) and (5Z)-7-Oxozeaenol (Cat. No. 499610) analog that inhibits several kinases via an initial affinity binding to the ATP pocket, followed by a covalent adduct formation with a conserved ATP site cysteine residue of the targeted enzymes, including, but not limited to, Flt1/VEGFR-1, Flt3, cKit(D816V), MAPK1, MAPK2, MEK1, MKK6, PKCμ, PKD2, PRAK, and Tak1 (≥90% inhibition at 2 µM). Hypothemycin is also reported to inhibit two non-RAL targets (99% and 82% inhibition of TrkA and TrkB, respectively, at 2 µM), while one of the 46 putative cis-enone RALs targets, namely GSK-3α, is shown not to be affected. Hypothemycin inhibits multiple kinases involved in MAP kinase pathways and is therefore particularly effective in inhibiting BRAF(V600E)-dependent tumor growth. (5Z)-Zeaenol (Cat. No. 499609) may serve as a negative control.
      Catalogue Number401011
      Brand Family Calbiochem®
      SynonymsNSC 354462
      References
      ReferencesSchirmer, A., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 4234.
      Solit, D.B., et al. 2006. Nature 439, 358.
      Tanaka, H., et al. 1999. Jpn. J. Cancer Res. 90, 1139.
      Product Information
      CAS number76958-67-3
      FormLyophilized solid
      Hill FormulaC₁₉H₂₂O₈
      Chemical formulaC₁₉H₂₂O₈
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      401011 0

      Documentation

      Hypothemycin - CAS 76958-67-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Hypothemycin - CAS 76958-67-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      401011

      References

      Reference overview
      Schirmer, A., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 4234.
      Solit, D.B., et al. 2006. Nature 439, 358.
      Tanaka, H., et al. 1999. Jpn. J. Cancer Res. 90, 1139.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2010 RFH
      SynonymsNSC 354462
      DescriptionA cell-permeable cis-enone resorlic acid lactone (RAL) and (5Z)-7-Oxozeaenol (Cat. No. 499610) analog that inhibits several kinases via an initial affinity binding to the ATP pocket, followed by a covalent adduct formation with a conserved ATP site cysteine residue of the targeted enzymes, including, but not limited to, Flt1/VEGFR-1, Flt3, cKit(D816V), MAPK1, MAPK2, MEK1, MKK6, PKCµ, PKD2, PRAK, and Tak1 (≥90% inhibition at 2 µM). Hypothemycin is also reported to inhibit two non-RAL targets (99% and 82% inhibition of TrkA and TrkB, respectively, at 2 µM), while one of the 46 putative cis-enone RALs targets, namely GSK-3α, is shown not to be affected. Hypothemycin inhibits multiple kinases involved in MAP kinase pathways and is therefore particularly effective in inhibiting BRAF(V600E)-dependent tumor growth. (5Z)-Zeaenol (Cat. No. 499609) may serve as a negative control.
      FormLyophilized solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number76958-67-3
      Chemical formulaC₁₉H₂₂O₈
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSchirmer, A., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 4234.
      Solit, D.B., et al. 2006. Nature 439, 358.
      Tanaka, H., et al. 1999. Jpn. J. Cancer Res. 90, 1139.