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407248 IGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem

The IGF-1R Inhibitor II, also referenced under CAS 196868-63-0, controls the biological activity of IGF-1R. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(2-Methoxy-5-chlorophenyl)-Nʹ-(2-methylquinolin-4-yl)-urea, PQ401

Primary Target: IGF-1R
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      196868-63-0C₁₈H₁₆ClN₃O₂
      Description
      OverviewA cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation (IC50 = 12 µM in inhibiting ligand-induced autophosphorylation in MCF-7 cells and < 1 µM in a cell-free kinase assay). Reduces IGF-1R-dependent tumor cell growth both in vitro (IC50 = 8 and 15 µM for MCF-7 and MCNeuA, respectively) and in mice in vivo (80% reduction, 100 mg/kg thrice a week, i.p.). The mechanism of inhibition probably involves indirect blocking of ATP binding.
      Catalogue Number407248
      Brand Family Calbiochem®
      SynonymsN-(2-Methoxy-5-chlorophenyl)-Nʹ-(2-methylquinolin-4-yl)-urea, PQ401
      References
      ReferencesGable, K.L., et al. 2006. Mol. Cancer Ther. 5, 1079.
      Product Information
      CAS number196868-63-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₈H₁₆ClN₃O₂
      Chemical formulaC₁₈H₁₆ClN₃O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetIGF-1R
      Primary Target IC<sub>50</sub>12 µM in inhibiting ligand-induced IGF-1R autophosphorylation in MCF-7 cells and < 1 µM in a cell-free kinase assay; 8 and 15 µM in reducing IGF-1R-dependent tumor cell growth both in vitro for MCF-7 and MCNeuA, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      407248 0

      Documentation

      IGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      IGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      407248

      References

      Reference overview
      Gable, K.L., et al. 2006. Mol. Cancer Ther. 5, 1079.

      Brochure

      Title
      Insulin Pathway Poster PDF ( 618 KB )
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      SynonymsN-(2-Methoxy-5-chlorophenyl)-Nʹ-(2-methylquinolin-4-yl)-urea, PQ401
      DescriptionA cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation (IC50 = 12 µM in inhibiting ligand-induced autophosphorylation in MCF-7 cells and < 1 µM in a cell-free kinase assay). Reduces IGF-1R-dependent tumor cell growth both in vitro (IC50 = 8 and 15 µM for MCF-7 and MCNeuA, respectively) and in mice in vivo (80% reduction, 100 mg/kg thrice a week per i.p.). The mechanism of inhibition probably involves indirect blocking of ATP binding.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number196868-63-0
      Chemical formulaC₁₈H₁₆ClN₃O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (3 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesGable, K.L., et al. 2006. Mol. Cancer Ther. 5, 1079.