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401474 IKK Inhibitor II, Wedelolactone - CAS 524-12-9 - Calbiochem

IKK Inhibitor II, Wedelolactone, CAS 524-12-9, is a cell-permeable, selective, irreversible inhibitor of IKKα and β kinase activity (IC50 = 10 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Wedelolactone, Eclipta alba, 7-Methoxy-5,11,12-trihydroxy-coumestan

Primary Target: IKKα and β kinase activity
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      524-12-9C₁₆H₁₀O₇
      Description
      OverviewThe naturally isolated active ingredient of the herbal medicine, Eclipta alba, that acts as a cell permeable, selective and irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 µM). Inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Has no effects on p38 MAP kinase or Akt.
      Catalogue Number401474
      Brand Family Calbiochem®
      SynonymsWedelolactone, Eclipta alba, 7-Methoxy-5,11,12-trihydroxy-coumestan
      References
      ReferencesKobori, M., et al. 2004. Cell Death Differ. 11, 123.
      Li, C.C., et al. 2003. J. Org. Chem. 68, 8500.
      Mors, W.B., et al. 1989. Toxicon 27, 1003.
      Wagner, H., and Fessler, B. 1986. Planta Med. 5, 374.
      Product Information
      CAS number524-12-9
      ATP CompetitiveN
      FormYellowish-green, crystalline powder
      Hill FormulaC₁₆H₁₀O₇
      Chemical formulaC₁₆H₁₀O₇
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationIKK Inhibitor II, Wedelolactone, CAS 524-12-9, is a cell-permeable, selective, irreversible inhibitor of IKKα and β kinase activity (IC50 = 10 µM).
      Biological Information
      Primary TargetIKKα and β kinase activity
      Primary Target IC<sub>50</sub>< 10 µM against IKKα and β kinase activity
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      401474 0

      Documentation

      IKK Inhibitor II, Wedelolactone - CAS 524-12-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      IKK Inhibitor II, Wedelolactone - CAS 524-12-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      401474

      References

      Reference overview
      Kobori, M., et al. 2004. Cell Death Differ. 11, 123.
      Li, C.C., et al. 2003. J. Org. Chem. 68, 8500.
      Mors, W.B., et al. 1989. Toxicon 27, 1003.
      Wagner, H., and Fessler, B. 1986. Planta Med. 5, 374.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-October-2009 RFH
      SynonymsWedelolactone, Eclipta alba, 7-Methoxy-5,11,12-trihydroxy-coumestan
      DescriptionCell-permeable. The naturally-occuring active ingredient from the herbal medicine, Eclipta alba, that acts as a selective and irreversible inhibitor of IKKα and IKKβ kinase activities (IC50 < 10 µM). Inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Does not affect the activities of p38 MAP kinase or Akt.
      FormYellowish-green, crystalline powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number524-12-9
      Chemical formulaC₁₆H₁₀O₇
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml) or Methanol (1 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKobori, M., et al. 2004. Cell Death Differ. 11, 123.
      Li, C.C., et al. 2003. J. Org. Chem. 68, 8500.
      Mors, W.B., et al. 1989. Toxicon 27, 1003.
      Wagner, H., and Fessler, B. 1986. Planta Med. 5, 374.