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407653 Interleukin-6 Receptor, Soluble, Human, Recombinant, S. frugiperda

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: rhIL-6 sR

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407653
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Overview

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407653-25UG
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      		 Plastic ampoule 25 μg
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      Description
      OverviewRecombinant, human soluble interleukin-6 receptor expressed in S. frugiperda insect cells. Soluble form of the IL-6 receptor that binds IL-6 and mediates IL-6 signaling through interaction with gp130. Elevated serum levels of soluble IL-6 receptors have been shown to be associated with a number of pathological states including multiple myelomas, adult T cell leukemia, interstitial lung infection, and HIV infection.
      Catalogue Number407653
      Brand Family Calbiochem®
      SynonymsrhIL-6 sR
      References
      ReferencesSchobitz, B., et al. 1995. FASEB J. 9, 659.
      Yokoyama, A., et al. 1995. Clin. Exp. Immunol. 100, 325.
      Suzuki, H., et al. 1993. Eur. J. Immunol. 23, 1078.
      Lust, J.A., et al. 1992. Cytokine 4, 96.
      Sugita, T., et al. 1990. J. Exp. Med. 171, 2001.
      Yamasaki, K., et al. 1988. Science 241, 825.
      Product Information
      FormLyophilized
      FormulationLyophilized from sterile-filtered PBS, 50 µg BSA/µg IL-6 receptor.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityED₅₀= ≥5 ng/ml as measured by its ability to enhance IL-6-induced growth inhibition of mouse M1 myeloid leukemic cells
      Purity≥97% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: ≤1 EU/µg
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C. Avoid freeze/thaw cycles of solutions.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      407653-25UG 04055977211412

      Documentation

      Interleukin-6 Receptor, Soluble, Human, Recombinant, S. frugiperda SDS

      Title

      Safety Data Sheet (SDS) 

      Interleukin-6 Receptor, Soluble, Human, Recombinant, S. frugiperda Certificates of Analysis

      TitleLot Number
      407653

      References

      Reference overview
      Schobitz, B., et al. 1995. FASEB J. 9, 659.
      Yokoyama, A., et al. 1995. Clin. Exp. Immunol. 100, 325.
      Suzuki, H., et al. 1993. Eur. J. Immunol. 23, 1078.
      Lust, J.A., et al. 1992. Cytokine 4, 96.
      Sugita, T., et al. 1990. J. Exp. Med. 171, 2001.
      Yamasaki, K., et al. 1988. Science 241, 825.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-May-2010 JSW
      SynonymsrhIL-6 sR
      DescriptionRecombinant, human soluble interleukin-6 receptor expressed in S. frugiperda insect cells. Soluble form of the IL-6 receptor that binds IL-6 and mediates IL-6 signaling through interaction with gp 130. Elevated serum levels of soluble IL-6 receptors have been shown to be associated with a number of pathological states, including multiple myelomas, adult T cell leukemia, interstitial lung infection, and HIV infection.
      FormLyophilized
      FormulationLyophilized from sterile-filtered PBS, 50 µg BSA/µg IL-6 receptor.
      Purity≥97% by SDS-PAGE
      ContaminantsEndotoxin: ≤1 EU/µg
      Biological activityED₅₀= ≥5 ng/ml as measured by its ability to enhance IL-6-induced growth inhibition of mouse M1 myeloid leukemic cells
      SolubilityReconstitute to a concentration ≥100 µg/ml with sterile PBS containing at least 0.1% HSA or BSA.
      Storage ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C. Avoid freeze/thaw cycles of solutions.
      Toxicity Standard Handling
      ReferencesSchobitz, B., et al. 1995. FASEB J. 9, 659.
      Yokoyama, A., et al. 1995. Clin. Exp. Immunol. 100, 325.
      Suzuki, H., et al. 1993. Eur. J. Immunol. 23, 1078.
      Lust, J.A., et al. 1992. Cytokine 4, 96.
      Sugita, T., et al. 1990. J. Exp. Med. 171, 2001.
      Yamasaki, K., et al. 1988. Science 241, 825.

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      Categories

      Life Science Research > Proteins and Enzymes > Other Proteins