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454861 MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem

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Overview

Key Specifications Table

CAS #Empirical Formula
522629-08-9C₁₁H₉FN₆
Description
OverviewA cell-permeable, reversible, and ATP-competitive pyrazolo-pyrimidine compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 1 (MNK1; IC50 = 2.2 µM) with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. Effectively inhibits eIF4E phosphorylation (IC50 = 3 µM) by MNK1 in 293 human embryonic kidney cells and serves as a useful tool in studying MNK1-mediated cellular signaling.
Catalogue Number454861
Brand Family Calbiochem®
Synonyms4-Amino-5-(4-fluoroanilino)-pyrazolo[3,4-d]pyrimidine, MNK Inhibitor I, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor I, CGP 57380
References
ReferencesTopisirovic, I., et al. 2004. Cancer Res. 64, 8639.
Worch, J., et al. 2004. Oncogene 23, 9162.
Walsh, D., and Mohr, I. 2004. Genes Dev. 18, 660.
Morley, S.J., and Naegele, S. 2002. J. Biol. Chem. 277, 32855.
Knauf, U., et al. 2001. Mol. Cell. Biol. 21, 5500.
Product Information
CAS number522629-08-9
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₁₁H₉FN₆
Chemical formulaC₁₁H₉FN₆
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetMitogen-activated protein kinase-interacting kinase 1 (MNK1)
Primary Target IC<sub>50</sub>2.2 µM against mitogen-activated protein kinase-interacting kinase 1 (MNK1); 3 µM against eIF4E phosphorylation by MNK1 in 293 human embryonic kidney cells
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalog Number GTIN
454861 0