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444170 Manumycin A, Streptomyces parvulus - CAS 52665-74-4 - Calbiochem

An antibiotic with antitumor properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Farnesyltransferase (FTAse)
444170
  
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      52665-74-4C₃₁H₃₈N₂O₇
      Description
      OverviewAn antibiotic with antitumor properties. A cell-permeable potent and selective inhibitor of farnesyltransferase (FTase; IC50 = 5 µM) compared to geranylgeranyltransferase I (GGTase I; IC50 = 180 µM). Manumycin acts as a competitive inhibitor of FTase with respect to farnesylpyrophosphate (FPP; Ki = 1.2 µM), but acts as a noncompetitive inhibitor with respect to the Ras acceptor protein. Reported to inhibit the growth and invasive activity of pancreatic cancer cells.
      Catalogue Number444170
      Brand Family Calbiochem®
      References
      ReferencesKainuma, O., et al. 1997. Pancreas 15, 379.
      Nagase, T., et al. 1996. Int. J. Cancer 65, 620.
      Hara, M., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 3333.
      Hara, M., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2281.
      Tamanoi, R. 1993. Trends Biochem. Sci. 18, 349.
      Product Information
      CAS number52665-74-4
      ATP CompetitiveN
      FormYellow to brown solid
      Hill FormulaC₃₁H₃₈N₂O₇
      Chemical formulaC₃₁H₃₈N₂O₇
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFarnesyltransferase (FTAse)
      Primary Target IC<sub>50</sub>5 µM against farnesyltransferase (FTase); 180 µM against geranylgeranyltransferase I (GGTase I)
      Purity≥96% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      444170 0

      Documentation

      Manumycin A, Streptomyces parvulus - CAS 52665-74-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Manumycin A, Streptomyces parvulus - CAS 52665-74-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      444170

      References

      Reference overview
      Kainuma, O., et al. 1997. Pancreas 15, 379.
      Nagase, T., et al. 1996. Int. J. Cancer 65, 620.
      Hara, M., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 3333.
      Hara, M., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2281.
      Tamanoi, R. 1993. Trends Biochem. Sci. 18, 349.

      Citations

      Title
    • Karen E. Porter, et al. (2004) Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA. Cardiovascular Research 61, 745-755.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-May-2009 JSW
      DescriptionAn antibiotic with antitumor properties. A potent and selective inhibitor of farnesyltransferase (FTase, IC50 = 5 µM) compared to geranyl-geranyltransferase I (GGTase, IC50 = 180 µM). Manumycin acts as a competitive inhibitor of FTase with respect to farnesylpyrophosphate (FPP, Ki = 1.2 µM), but as a noncompetitive inhibitor with respect to the Ras acceptor protein. Reported to inhibit the growth and invasive activity of pancreatic cancer cells.
      FormYellow to brown solid
      CAS number52665-74-4
      Chemical formulaC₃₁H₃₈N₂O₇
      Structure formulaStructure formula
      Purity≥96% by HPLC
      SolubilityDMSO (10 mg/ml), Methanol or Chloroform
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesKainuma, O., et al. 1997. Pancreas 15, 379.
      Nagase, T., et al. 1996. Int. J. Cancer 65, 620.
      Hara, M., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 3333.
      Hara, M., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2281.
      Tamanoi, R. 1993. Trends Biochem. Sci. 18, 349.
      Citation
    • Karen E. Porter, et al. (2004) Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA. Cardiovascular Research 61, 745-755.
      		•