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474700 Mevastatin - CAS 73573-88-3 - Calbiochem

An antibiotic that acts as a potent inhibitor of HMG-CoA reductase, thus suppressing Ras farnesylation.

Mevastatin - CAS 73573-88-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Compactin

Primary Target: HMG-CoA reductase
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474700
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
73573-88-3C₂₃H₃₄O₅

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474700-50MG
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      		 Plastic ampoule 50 mg
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      Description
      OverviewAn antibiotic that acts as a potent inhibitor of HMG-CoA reductase, thus suppressing Ras farnesylation. Inhibitor of myoblast fusion. Also may induce bone morphogenic protein-2 (BMP-2). Causes cell cycle arrest in late G1 phase.
      This is an inactive form which may require activation for use with isolated cells depending upon the application. To activate, treat with NaOH in ethanol and then neutralize to pH 7.2.
      Catalogue Number474700
      Brand Family Calbiochem®
      SynonymsCompactin
      References
      ReferencesSugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun. 271, 688.
      Hug, T., et al. 1995. Pflugers Archiv. Eur. J. Physiol. 429, 682.
      Belo, R.S., et al. 1993. Mol. Cell. Biochem. 126, 159.
      McLeish, K.R., et al. 1993. Biochem. Biophys. Res. Commun. 197, 763.
      Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
      Jackson, J.H., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 3042.
      Kita, T., et al. 1980. J. Clin. Invest. 66, 1094.
      Product Information
      CAS number73573-88-3
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₃H₃₄O₅
      Chemical formulaC₂₃H₃₄O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetHMG-CoA reductase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSEK7907100
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      474700-50MG 07790788050429

      Documentation

      Mevastatin - CAS 73573-88-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Mevastatin - CAS 73573-88-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      474700

      References

      Reference overview
      Sugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun. 271, 688.
      Hug, T., et al. 1995. Pflugers Archiv. Eur. J. Physiol. 429, 682.
      Belo, R.S., et al. 1993. Mol. Cell. Biochem. 126, 159.
      McLeish, K.R., et al. 1993. Biochem. Biophys. Res. Commun. 197, 763.
      Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
      Jackson, J.H., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 3042.
      Kita, T., et al. 1980. J. Clin. Invest. 66, 1094.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-August-2008 RFH
      SynonymsCompactin
      DescriptionAn antibiotic that acts as a potent inhibitor of HMG-CoA reductase, thus suppresses Ras farnesylation. Inhibitor of myoblast fusion. Causes cell cycle arrest in late G1 phase. May induce bone morphogenic protein-2 (BMP-2). This product requires activation for use in cell culture and cell-free assay systems. To activate, treat with ethanol solution with 1 N NaOH and then neutralize with 1 N HCl to pH 7.2 (see Keyomarsi, K . et al. 1991).
      FormWhite solid
      CAS number73573-88-3
      RTECSEK7907100
      Chemical formulaC₂₃H₃₄O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityEthanol
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 6164
      ReferencesSugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun. 271, 688.
      Hug, T., et al. 1995. Pflugers Archiv. Eur. J. Physiol. 429, 682.
      Belo, R.S., et al. 1993. Mol. Cell. Biochem. 126, 159.
      McLeish, K.R., et al. 1993. Biochem. Biophys. Res. Commun. 197, 763.
      Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
      Jackson, J.H., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 3042.
      Kita, T., et al. 1980. J. Clin. Invest. 66, 1094.