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475816 Microcystin-RR, Microcystis aeruginosa - CAS 111755-37-4 - Calbiochem

Arg-Arg analog of Microcystin-LR that is less toxic. Inhibits protein phosphatase 2A (IC₅₀ = 3.4 nM). Useful for comparative structure and function studies.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MCYST-RR

Primary Target: PP2A
475816
  
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      111755-37-4C₄₉H₇₅N₁₃O₁₂
      Description
      Overview

      This product has been discontinued.




      Arg-Arg analog of Microcystin-LR (Cat. No. 475815) that is less toxic. Inhibits protein phosphatase 2A (IC50 = 3.4 nM). Useful for comparative structure and function studies.
      Catalogue Number475816
      Brand Family Calbiochem®
      SynonymsMCYST-RR
      References
      ReferencesShirai, M., et al. 1991. Appl. Environ. Microbiol. 57, 1241.
      Mastsushima, R., et al. 1990. Biochem. Biophys. Res. Commun. 171, 867.
      Meriluoto, J.A., et al. 1990. J. Chromatography 509, 309.
      Carmichael, W.W. 1989. in Natural Toxins (Ownby, C.L., and O’Dell, G.V., Eds.) p. 3, Pergamon, Elmsford, New York.
      Product Information
      CAS number111755-37-4
      ATP CompetitiveN
      DeclarationNot available for sale outside of the United States.
      FormOff-white solid
      Hill FormulaC₄₉H₇₅N₁₃O₁₂
      Chemical formulaC₄₉H₇₅N₁₃O₁₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetPP2A
      Primary Target IC<sub>50</sub>3.4 nM inhibiting protein phosphatase 2A
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 26/27/28-36/37/38-43

      Very toxic by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      May cause sensitization by skin contact.
      S PhraseS: 26-36/37/39-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      End use certificateY
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      475816 0

      Documentation

      Microcystin-RR, Microcystis aeruginosa - CAS 111755-37-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Microcystin-RR, Microcystis aeruginosa - CAS 111755-37-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      475816

      References

      Reference overview
      Shirai, M., et al. 1991. Appl. Environ. Microbiol. 57, 1241.
      Mastsushima, R., et al. 1990. Biochem. Biophys. Res. Commun. 171, 867.
      Meriluoto, J.A., et al. 1990. J. Chromatography 509, 309.
      Carmichael, W.W. 1989. in Natural Toxins (Ownby, C.L., and O’Dell, G.V., Eds.) p. 3, Pergamon, Elmsford, New York.

      Brochure

      Title
      Protein Phosphatases Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-August-2008 RFH
      SynonymsMCYST-RR
      DescriptionArg-Arg analog of Microcystin-LR (Cat. No. 475815) that is less toxic. Inhibitor of protein-phosphatase 2A (IC50 = 3.4 nM). Useful for comparative structure and function studies.
      FormOff-white solid
      CAS number111755-37-4
      Chemical formulaC₄₉H₇₅N₁₃O₁₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (2.5 mg/ml) or Ethanol
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Highly Toxic
      ReferencesShirai, M., et al. 1991. Appl. Environ. Microbiol. 57, 1241.
      Mastsushima, R., et al. 1990. Biochem. Biophys. Res. Commun. 171, 867.
      Meriluoto, J.A., et al. 1990. J. Chromatography 509, 309.
      Carmichael, W.W. 1989. in Natural Toxins (Ownby, C.L., and O’Dell, G.V., Eds.) p. 3, Pergamon, Elmsford, New York.