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FCMAB289A4 Milli-Mark® Anti-PINK1-Alexa Fluor 488 Antibody, clone N4/49

Milli-Mark Anti-PINK1-Alexa Fluor 488 Antibody, clone N4/49 is an antibody against PINK1-Alexa Fluor 488 for use in FC.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: PINK1, PARK6, BRPK UniProt Number: Q9BXM7
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FCMAB289A4
100 tests  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFCMAlexaFluor®488Monoclonal Antibody
      Description
      Catalogue NumberFCMAB289A4
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark® Anti-PINK1-Alexa Fluor 488 Antibody, clone N4/49
      Alternate Names
      • PTEN induced putative kinase 1
      • protein kinase BRPK
      • serine/threonine-protein kinase PINK1
      • PTEN-induced putative kinase protein 1
      • Parkinson disease (autosomal recessive) 6
      Background InformationMutations in the PTEN-induced kinase 1 (PINK1) gene located within the PARK6 locus on chromosome 1p35-p36 have recently been identified in patients with recessive early-onset Parkinson disease. Data suggests that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance.
      References
      Product Information
      FormatAlexaFluor®488
      Control
      • HEK293 cells
      PresentationPurified mouse monoclonal IgG1k conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Quality LevelMQ100
      Applications
      ApplicationMilli-Mark Anti-PINK1-Alexa Fluor 488 Antibody, clone N4/49 is an antibody against PINK1-Alexa Fluor 488 for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenRecombinant protein corresponding to human PINK1.
      CloneN4/49
      HostMouse
      SpecificityAntibody recognizes human PINK1.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.
      Gene Symbol
      • PINK1
      • PARK6
      • BRPK
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins.

      CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

      COFACTOR: Magnesium.

      SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass membrane protein.

      TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.

      PTM: Autophosphorylated.

      INVOLVEMENT IN DISEASE: Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6) [MIM:605909]. A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.

      SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

      Contains 1 protein kinase domain.
      Molecular WeightUniprot describes two isoforms exist with calculated Mw of 63 and 30 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using HEK293 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      FCMAB289A4 04053252294945

      Documentation

      Milli-Mark® Anti-PINK1-Alexa Fluor 488 Antibody, clone N4/49 SDS

      Title

      Safety Data Sheet (SDS) 

      Milli-Mark® Anti-PINK1-Alexa Fluor 488 Antibody, clone N4/49 Certificates of Analysis

      TitleLot Number
      Milli-Mark#174; Anti-PINK1-Alexa Fluor#174; 488, clone N4/49 - NRG1937006 NRG1937006
      Milli-MarkTM Anti-PINK1-Alexa Fluor#174; 488, clone N4/49 - 2070847 2070847
      Milli-MarkTM Anti-PINK1-Alexa Fluor® -2567122 2567122
      Milli-MarkTM Anti-PINK1-Alexa Fluor® 488, clone N4/49 - 2329148 2329148
      Milli-MarkTM Anti-PINK1-Alexa Fluor® 488, clone N4/49 - 3465946 3465946
      Milli-MarkTM Anti-PINK1-Alexa Fluor® 488, clone N4/49 - 3744821 3744821
      Milli-MarkTM Anti-PINK1-Alexa Fluor® 488, clone N4/49 - 3866256 3866256
      Milli-MarkTM Anti-PINK1-Alexa Fluor® 488, clone N4/49 -2508537 2508537
      Milli-MarkTM Anti-PINK1-Alexa Fluor® 488, clone N4/49 -2538639 2538639
      Milli-MarkTM Anti-PINK1-Alexa Fluor® 488, clone N4/49 Conjugate 2952318
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