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475843 Minocycline, Hydrochloride - CAS 13614-98-7 - Calbiochem

Semi-synthetic tetracycline derivative effective against tetracycline-resistant staphylococci.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7-Dimethylamino-6-demethyl-6-deoxytetracycline, HCl

Primary Target: Metalloproteinase (MMP)
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      13614-98-7C₂₃H₂₇N₃O₇ · HCl
      Description
      Overview

      This product has been discontinued.



      Semi-synthetic tetracycline derivative effective against tetracycline-resistant staphylococci. A matrix metalloproteinase (MMP) inhibitor shown to inhibit tumor-induced angiogenesis. Inhibits stromelysin (MMP-3; IC50 = 290 µM) but does not inhibit other MMPs such as fibroblast collagenase or gelatinase. Potently inhibits PARP-1 (Ki = 13.4 nM) in a NAD+ - competitive manner. Exhibits anti-inflammatory effects and suppresses T cell proliferation.
      Catalogue Number475843
      Brand Family Calbiochem®
      Synonyms7-Dimethylamino-6-demethyl-6-deoxytetracycline, HCl
      References
      ReferencesConrad, C.A., et al. 2006. Proc. Natl. Acad, Sci. USA 103, 9685.
      Gilbertson-Breading, S., et al. 1995. Cancer Chemother. Pharmacol. 36, 418.
      Kloppenburg, M., et al. 1995. Clin. Exp. Immunol. 102, 635.
      Preus, H.R., et al. 1995. J. Clin. Periodontol. 22, 380.
      Weingart, J.D., et al. 1995. J. Neurosurg. 82, 635.
      Tamargo, R.J., et al. 1991. Cancer Res. 51, 672.
      Product Information
      CAS number13614-98-7
      ATP CompetitiveN
      FormDark yellow solid
      Hill FormulaC₂₃H₂₇N₃O₇ · HCl
      Chemical formulaC₂₃H₂₇N₃O₇ · HCl
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMetalloproteinase (MMP)
      Primary Target IC<sub>50</sub>290 µM against MMP-3
      Primary Target K<sub>i</sub>13.4 nM against PARP-1
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSQI7630500
      Safety Information
      R PhraseR: 33-36/37/38-63-64

      Danger of cumulative effects.
      Irritating to eyes, respiratory system and skin.
      Possible risk of harm to the unborn child.
      May cause harm to breastfed babies.
      S PhraseS: 22-45-36

      Do not breathe dust.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      475843 0

      Documentation

      Minocycline, Hydrochloride - CAS 13614-98-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Minocycline, Hydrochloride - CAS 13614-98-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      475843

      References

      Reference overview
      Conrad, C.A., et al. 2006. Proc. Natl. Acad, Sci. USA 103, 9685.
      Gilbertson-Breading, S., et al. 1995. Cancer Chemother. Pharmacol. 36, 418.
      Kloppenburg, M., et al. 1995. Clin. Exp. Immunol. 102, 635.
      Preus, H.R., et al. 1995. J. Clin. Periodontol. 22, 380.
      Weingart, J.D., et al. 1995. J. Neurosurg. 82, 635.
      Tamargo, R.J., et al. 1991. Cancer Res. 51, 672.

      Brochure

      Title
      Antibiotics Profiler
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-May-2008 RFH
      Synonyms7-Dimethylamino-6-demethyl-6-deoxytetracycline, HCl
      DescriptionSemi-synthetic tetracycline derivative effective against tetracycline-resistant staphylococci. A matrix metalloproteinase (MMP) inhibitor shown to inhibit tumor-induced angiogenesis. Inhibits stromelysin (MMP-3; IC50 = 290 µM) but does not inhibit other MMPs such as fibroblast collagenase or gelatinase. Potently inhibits PARP-1 (Ki = 13.4 nM) in a NAD+ - competitive manner. Exhibits anti-inflammatory effects and suppresses T cell proliferation.
      FormDark yellow solid
      CAS number13614-98-7
      RTECSQI7630500
      Chemical formulaC₂₃H₂₇N₃O₇ · HCl
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityH₂O (50 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 6202
      ReferencesConrad, C.A., et al. 2006. Proc. Natl. Acad, Sci. USA 103, 9685.
      Gilbertson-Breading, S., et al. 1995. Cancer Chemother. Pharmacol. 36, 418.
      Kloppenburg, M., et al. 1995. Clin. Exp. Immunol. 102, 635.
      Preus, H.R., et al. 1995. J. Clin. Periodontol. 22, 380.
      Weingart, J.D., et al. 1995. J. Neurosurg. 82, 635.
      Tamargo, R.J., et al. 1991. Cancer Res. 51, 672.