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475867 Mn-cpx 3 - Calbiochem

Mn-cpx 3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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475867
  
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₀H₂₀Cl₂MnO₆
      Description
      Overview

      This product has been discontinued.



      A cell-permeable manganese complex of 7-hydroxyflavone that acts as a superoxide dismustase (SOD) mimetic and a neuroprotective agent against radical-induced damages. Shown to prevent the reduction of NBT by O2– • (IC50 = 1.18 µM) and exhibit ~10 times higher potency than Trolox (Cat. No. 648471) in inhibiting lipid peroxidation (IC50 = 6.15 µM) in vitro. Suppresses MAP (methamphetamine)-induced brain hypermotility in mice and shows protective effects against learning and memory impairment in a murine ischemic model in vivo.
      Catalogue Number475867
      Brand Family Calbiochem®
      References
      ReferencesVajragupta, O., et al. 2003. Bioorg. Med. Chem. 11, 2329.
      Product Information
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₃₀H₂₀Cl₂MnO₆
      Chemical formulaC₃₀H₂₀Cl₂MnO₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSuperoxide dismustase (SOD) mimetic
      Primary Target IC<sub>50</sub>1.18 µM in preventing the reduction of NBT by O2- • in vitro
      Purity≥98% by elemental analysis
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      475867 0

      Documentation

      Mn-cpx 3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Mn-cpx 3 - Calbiochem Certificates of Analysis

      TitleLot Number
      475867

      References

      Reference overview
      Vajragupta, O., et al. 2003. Bioorg. Med. Chem. 11, 2329.

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-October-2007 RFH
      DescriptionA cell-permeable manganese complex of 7-hydroxyflavone that acts as a superoxide dismutase (SOD) mimetic and exhibits neuroprotective effects against radical-induced damage. Shown to prevent the reduction of NBT by O2− • (IC50 = 1.18 µM). Reported to exhibit ~10 times higher potency than Trolox (Cat. No. 648471) in inhibiting lipid peroxidation (IC50 = 6.15 µM) in vitro. Suppresses MAP (methamphetamine)-induced brain hypermotility in mice and shows protective effects against learning and memory impairment in a murine ischemic model.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₀H₂₀Cl₂MnO₆
      Structure formulaStructure formula
      Purity≥98% by elemental analysis
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesVajragupta, O., et al. 2003. Bioorg. Med. Chem. 11, 2329.