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475944 Myeloperoxidase Inhibitor-I - CAS 5351-17-7 - Calbiochem

The Myeloperoxidase Inhibitor-I, also referenced under CAS 5351-17-7, controls the biological activity of Myeloperoxidase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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475944
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
5351-17-7C₇H₉N₃O

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475944-1GM
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      Description
      OverviewA benzoic acid hydrazide analog that acts as a potent, irreversible, and specific inhibitor of the peroxidation activity of myeloperoxidase (MPO; IC50 = 300 nM). Does not inhibit catalase or glutathione peroxidase activities. Does not affect the production of superoxide by neutrophils. Shown to inhibit H2O2-induced apoptosis in HL-60, human leukemia cells.
      Catalogue Number475944
      Brand Family Calbiochem®
      References
      ReferencesEngelmann, I., et al. 2000. Redox Report 5, 207.
      Wagner, B.A., et al. 2000. J. Biol. Chem. 275, 22461.
      Burner, U., et al. 1999. J. Biol. Chem. 274, 9494.
      Kettle, A.J., et al. 1997. Biochem. J. 321, 503.
      Kettle, A.J., et al. 1995. Biochem. J. 308, 559.
      Product Information
      CAS number5351-17-7
      ATP CompetitiveN
      FormWhite to beige powder
      Hill FormulaC₇H₉N₃O
      Chemical formulaC₇H₉N₃O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMyeloperoxidase
      Primary Target IC<sub>50</sub>300 nM against myeloperoxidase (MPO)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSDG2580000
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      475944-1GM 04055977184266

      Documentation

      Myeloperoxidase Inhibitor-I - CAS 5351-17-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Myeloperoxidase Inhibitor-I - CAS 5351-17-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      475944

      References

      Reference overview
      Engelmann, I., et al. 2000. Redox Report 5, 207.
      Wagner, B.A., et al. 2000. J. Biol. Chem. 275, 22461.
      Burner, U., et al. 1999. J. Biol. Chem. 274, 9494.
      Kettle, A.J., et al. 1997. Biochem. J. 321, 503.
      Kettle, A.J., et al. 1995. Biochem. J. 308, 559.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-August-2020 JSW
      DescriptionA benzoic acid hydrazide analog that acts as a potent, specific, and irreversible inhibitor of myeloperoxidase. ABAH is a mechanism-based inhibitor that is oxidized to radical intermediates that, in turn, promote the irreversible inactivation of myeloperoxidase. Reported to inhibit hypochlorous acid (HOCl) production by purified myeloperoxidase (IC50 = 300 nM). Has also been shown to inhibit HOCl production up to 90% in zymosan and phorbol myristate acetate stimulated neutrophils (IC50 = 16 µM and 2.2 µM, respectively). Does not affect superoxide radical production or degranulation of neutrophils and does not inhibit catalase or glutathione peroxidase. Shown to inhibit myeloperoxidase-mediated apoptosis in >90% of ras-expressing fibroblasts and glutathione-depleted, src-transformed cells. Also shown to inhibit apoptosis in H2O2-treated HL-60 promyelocytic leukemia cells.
      FormWhite to beige powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number5351-17-7
      RTECSDG2580000
      Chemical formulaC₇H₉N₃O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml) and dilute acids
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesEngelmann, I., et al. 2000. Redox Report 5, 207.
      Wagner, B.A., et al. 2000. J. Biol. Chem. 275, 22461.
      Burner, U., et al. 1999. J. Biol. Chem. 274, 9494.
      Kettle, A.J., et al. 1997. Biochem. J. 321, 503.
      Kettle, A.J., et al. 1995. Biochem. J. 308, 559.