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203995 N-tert-Butyl-α-phenylnitrone - CAS 3376-24-7 - Calbiochem

Most commonly-used free radical trap.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PBN

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203995
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
3376-24-7C₁₁H₁₅NO

Pricing & Availability

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203995-500MG
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      		 Plastic ampoule 500 mg
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      Description
      OverviewMost commonly-used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.
      Catalogue Number203995
      Brand Family Calbiochem®
      SynonymsPBN
      References
      ReferencesFloyd, R.A. 1997. Adv. Pharmacol. 38, 361.
      Miyajima, T., and Kotake, Y. 1995. Biochem. Biophys. Res. Commun. 215, 114.
      Jazen, E.G., et al. 1994. in Frontiers of Reactive Oxygen Species in Biology and Medicine, (Asada, K., and Yoshikawa, T., eds.), pp. 431-434. Elsevier Science, Amsterdam.
      Floyd, R.A. 1990. FASEB J. 4, 2587.
      Product Information
      CAS number3376-24-7
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₁H₁₅NO
      Chemical formulaC₁₁H₁₅NO
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFree radical trap
      Purity≥98% by GC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in DMSO aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 2 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      203995-500MG 04055977220018

      Documentation

      N-tert-Butyl-α-phenylnitrone - CAS 3376-24-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      N-tert-Butyl-α-phenylnitrone - CAS 3376-24-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      203995

      References

      Reference overview
      Floyd, R.A. 1997. Adv. Pharmacol. 38, 361.
      Miyajima, T., and Kotake, Y. 1995. Biochem. Biophys. Res. Commun. 215, 114.
      Jazen, E.G., et al. 1994. in Frontiers of Reactive Oxygen Species in Biology and Medicine, (Asada, K., and Yoshikawa, T., eds.), pp. 431-434. Elsevier Science, Amsterdam.
      Floyd, R.A. 1990. FASEB J. 4, 2587.

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-May-2008 RFH
      SynonymsPBN
      DescriptionMost commonly used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative diseases. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.
      FormWhite solid
      CAS number3376-24-7
      Chemical formulaC₁₁H₁₅NO
      Structure formulaStructure formula
      Purity≥98% by GC
      SolubilityDMSO (10 mg/ml), H₂O (20 mg/ml), or Chloroform (50 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in DMSO aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 2 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.
      Toxicity Standard Handling
      ReferencesFloyd, R.A. 1997. Adv. Pharmacol. 38, 361.
      Miyajima, T., and Kotake, Y. 1995. Biochem. Biophys. Res. Commun. 215, 114.
      Jazen, E.G., et al. 1994. in Frontiers of Reactive Oxygen Species in Biology and Medicine, (Asada, K., and Yoshikawa, T., eds.), pp. 431-434. Elsevier Science, Amsterdam.
      Floyd, R.A. 1990. FASEB J. 4, 2587.