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483120 NG-Nitro-L-arginine

NG-Nitro-L-arginine MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: L-NNA, NG-NO₂-L-Arg

Primary Target: bNOS
483120
  
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      2149-70-4C₆H₁₃N₅O₄
      Description
      Overview

      This product has been discontinued.





      A cell-permeable, potent and reversible inhibitor of bNOS and eNOS (Ki = 25 nM for bNOS; Ki = 90 nM for eNOS). Inhibits iNOS at much higher concentrations (Ki = 8.1 µM). Causes a reduction in cardiac output and profound vasoconstriction.
      Catalogue Number483120
      Brand Family Calbiochem®
      SynonymsL-NNA, NG-NO₂-L-Arg
      References
      ReferencesReif, D.W., and McCreedy, S.A. 1995. Arch. Biochem. Biophys. 320, 170.
      Modin, A., et al. 1994. Neuroscience 62, 189.
      Furfine, E.S., et al. 1993. Biochemistry 32, 8512.
      Michel, A.D., et al. 1993. Br. J. Pharmacol. 109, 287.
      Dawson, V.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 6368.
      Moore, P.K., et al. 1990. Br. J. Pharmacol. 99, 408.
      Product Information
      CAS number2149-70-4
      FormWhite to off-white lyophilized powder
      Hill FormulaC₆H₁₃N₅O₄
      Chemical formulaC₆H₁₃N₅O₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetbNOS
      Primary Target K<sub>i</sub>25 nM
      Secondary targeteNOS (Ki = 90 nM for eNOS), iNOS (Ki = 8.1 µM)
      Purity≥99% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      483120 0

      Documentation

      NG-Nitro-L-arginine Certificates of Analysis

      TitleLot Number
      483120

      References

      Reference overview
      Reif, D.W., and McCreedy, S.A. 1995. Arch. Biochem. Biophys. 320, 170.
      Modin, A., et al. 1994. Neuroscience 62, 189.
      Furfine, E.S., et al. 1993. Biochemistry 32, 8512.
      Michel, A.D., et al. 1993. Br. J. Pharmacol. 109, 287.
      Dawson, V.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 6368.
      Moore, P.K., et al. 1990. Br. J. Pharmacol. 99, 408.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-August-2008 RFH
      SynonymsL-NNA, NG-NO₂-L-Arg
      DescriptionA potent inhibitor of bNOS and eNOS (Ki = 25 nM for bNOS; Ki = 90 nM for eNOS). Also inhibits iNOS (Ki = 8.1 µM). Causes a reduction in cardiac output and profound vasoconstriction.
      FormWhite to off-white lyophilized powder
      CAS number2149-70-4
      Chemical formulaC₆H₁₃N₅O₄
      Structure formulaStructure formula
      Purity≥99% by TLC
      SolubilityH₂O
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesReif, D.W., and McCreedy, S.A. 1995. Arch. Biochem. Biophys. 320, 170.
      Modin, A., et al. 1994. Neuroscience 62, 189.
      Furfine, E.S., et al. 1993. Biochemistry 32, 8512.
      Michel, A.D., et al. 1993. Br. J. Pharmacol. 109, 287.
      Dawson, V.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 6368.
      Moore, P.K., et al. 1990. Br. J. Pharmacol. 99, 408.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Nitric Oxide and Oxidative Stress > Nitric Oxide Synthase (NOS) Inhibitors