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492000 NOX Inhibitor III, VAS2870 - CAS 722456-31-7 - Calbiochem

The NOX Inhibitor III, VAS2870, also referenced under CAS 722456-31-7, controls the biological activity of NOX.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide, NADPH Oxidase Inhibitor III, VAS2870

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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      722456-31-7C₁₈H₁₂N₆OS
      Description
      OverviewA cell-permeable thiotriazolopyrimidine compound that acts as an effective NADPH oxidase (NOX) inhibitor (IC50 = 10.6 µM against NOX activity in human neutrophil lysates) and is widely used for studying NOX-dependent cellular ROS formations in various cultures, including oxLDL-treated HUVEC (complete inhibition at 5 µM), PDGF-induced primary rat VSMC (vascular smooth muscle cells; complete inhibition at 10 µM), as well as aortic sections from spontaneously hypertensive rats (72% inhibition at 10 µM) ex vivo.
      Catalogue Number492000
      Brand Family Calbiochem®
      Synonyms7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide, NADPH Oxidase Inhibitor III, VAS2870
      References
      ReferencesWind, S., et al. 2010. Hypertension 56, 490.
      Lange, S., et al. 2009. Cardiovasc. Res. 81, 159.
      Stielow, C., et al. 2006. Biochem. Biophys. Res. Commun. 344, 200.
      ten Freyhaus, H., et al. 2006. Cardiovasc. Res. 71, 331.
      Product Information
      CAS number722456-31-7
      FormTan solid
      Hill FormulaC₁₈H₁₂N₆OS
      Chemical formulaC₁₈H₁₂N₆OS
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      492000 0

      Documentation

      NOX Inhibitor III, VAS2870 - CAS 722456-31-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      NOX Inhibitor III, VAS2870 - CAS 722456-31-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      492000

      References

      Reference overview
      Wind, S., et al. 2010. Hypertension 56, 490.
      Lange, S., et al. 2009. Cardiovasc. Res. 81, 159.
      Stielow, C., et al. 2006. Biochem. Biophys. Res. Commun. 344, 200.
      ten Freyhaus, H., et al. 2006. Cardiovasc. Res. 71, 331.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-April-2012 JSW
      Synonyms7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide, NADPH Oxidase Inhibitor III, VAS2870
      DescriptionA cell-permeable thiotriazolopyrimidine compound that acts as an effective NADPH oxidase (NOX) inhibitor (IC50 = 10.6 µM against NOX activity in human neutrophil lysates) and is widely used for studying NOX-dependent cellular ROS formations in various cultures, including oxLDL-treated HUVEC (complete inhibition at 5 µM), PDGF-induced primary rat VSMC (vascular smooth muscle cells; complete inhibition at 10 µM), as well as aortic sections from spontaneously hypertensive rats (SHRs) (72% inhibition at 10 µM). Also shown to inhibit PDGF-BB-induced murine EB (embryonid body) vacularization (74% inhibition at 50 µM) and improve ACh-induced vasorelaxation of isolated rat aortic rings from both SHRs and non-hypertensive rats ex vivo (by 41.7 and 34.5%, respectively, at 10 µM).
      FormTan solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number722456-31-7
      Chemical formulaC₁₈H₁₂N₆OS
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesWind, S., et al. 2010. Hypertension 56, 490.
      Lange, S., et al. 2009. Cardiovasc. Res. 81, 159.
      Stielow, C., et al. 2006. Biochem. Biophys. Res. Commun. 344, 200.
      ten Freyhaus, H., et al. 2006. Cardiovasc. Res. 71, 331.