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4801 Neomycin Sulfate - CAS 1405-10-3 - Calbiochem

Neomycin Sulfate, CAS 1405-10-3, is an aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      1405-10-3C₂₃H₄₆N₆O₁₃ . 3H₂SO₄
      Description
      OverviewAn aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes. Recently shown to inhibit angiogenin-induced angiogenesis. Blocks voltage-sensitive Ca2+ channels without affecting Na+ - Ca2+ antiporter in nerve cells. A potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release. An inhibitor of inositol phospholipid turnover. A non-specific phospholipase C inhibitor. Also inhibits phosphatidylcholine-phospholipase D activity (IC50 = 65 µM). Inhibits angiogenin-induced angiogenesis in the chicken chorioallantoic membrane (20 ng per egg).
      Catalogue Number4801
      Brand Family Calbiochem®
      References
      ReferencesHu, G.F. 1998. Proc. Natl. Acad. Sci. USA 95, 9791.
      Wang, J.P., et al. 1996. J. Biol. Chem. 271, 8387.
      Smith, M.J., et al. 1995. Dev. Biol. 167, 239.
      Phillippe, M. 1994. Biochem. Biophys. Res. Commun. 205, 245.
      Canzoniero, L.M., et al. 1993. Eur. J. Pharmacol. 245, 97.
      Liscovitch, M., et al. 1991. Biochem. J. 279, 319.
      Product Information
      CAS number1405-10-3
      Activity≥600 IU/mg
      FormWhite solid
      Hill FormulaC₂₃H₄₆N₆O₁₃ . 3H₂SO₄
      Chemical formulaC₂₃H₄₆N₆O₁₃ . 3H₂SO₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      ApplicationNeomycin Sulfate, CAS 1405-10-3, is an aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes.
      Biological Information
      Primary Targetangiogenin-induced angiogenesis
      Primary Target K<sub>i</sub>phosphatidylcholine-phospholipase D activity (IC₅₀ = 65 µM), inhibits angiogenin-induced angiogenesis in the chicken chorioallantoic membrane (20 ng per egg)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSQP4375000
      Safety Information
      R PhraseR: 42/43-60-61

      May cause sensitization by inhalation and skin contact.
      May impair fertility.
      May cause harm to the unborn child.
      S PhraseS: 22-36/37-45

      Do not breathe dust.
      Wear suitable protective clothing and gloves.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store at room temperature (20°C). Stock solutions are stable for up to 3 months at 20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      4801 0

      Documentation

      Neomycin Sulfate - CAS 1405-10-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Neomycin Sulfate - CAS 1405-10-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      4801

      References

      Reference overview
      Hu, G.F. 1998. Proc. Natl. Acad. Sci. USA 95, 9791.
      Wang, J.P., et al. 1996. J. Biol. Chem. 271, 8387.
      Smith, M.J., et al. 1995. Dev. Biol. 167, 239.
      Phillippe, M. 1994. Biochem. Biophys. Res. Commun. 205, 245.
      Canzoniero, L.M., et al. 1993. Eur. J. Pharmacol. 245, 97.
      Liscovitch, M., et al. 1991. Biochem. J. 279, 319.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-October-2007 JSW
      DescriptionAn aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes. Recetly shown to inhibit angiogenin-induced angiogenesis. Blocks voltage-sensitive Ca2+ channels without affecting the Na+-Ca2+ antiporter in nerve cells. A potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release. An inhibitor of inositol phospholipid turnover. A non-specific phosolipase C inhibitor. Also inhibits phophatidylcholine-phospholipase D activity (IC50 = 65 µM).
      FormWhite solid
      CAS number1405-10-3
      RTECSQP4375000
      Chemical formulaC₂₃H₄₆N₆O₁₃ . 3H₂SO₄
      Structure formulaStructure formula
      Activity≥600 IU/mg
      SolubilityH₂O (6 mg/ml)
      Storage Protect from moisture
      Protect from light
      +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store at room temperature (20°C). Stock solutions are stable for up to 3 months at 20°C.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 6454
      ReferencesHu, G.F. 1998. Proc. Natl. Acad. Sci. USA 95, 9791.
      Wang, J.P., et al. 1996. J. Biol. Chem. 271, 8387.
      Smith, M.J., et al. 1995. Dev. Biol. 167, 239.
      Phillippe, M. 1994. Biochem. Biophys. Res. Commun. 205, 245.
      Canzoniero, L.M., et al. 1993. Eur. J. Pharmacol. 245, 97.
      Liscovitch, M., et al. 1991. Biochem. J. 279, 319.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Phospholipase Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Biochemicals > Antibiotics > Antimicrobial Agents