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533087 Niclosamide Ethanolamine - Calbiochem

Niclosamide Ethanolamine, NEN, AMPK activator

Niclosamide Ethanolamine - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NEN

533087
  
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₃H₈Cl₂N₂O₄·C₂H₇NO
      Description
      Overview

      This product has been discontinued.



      A cell permeable, orally bioavailable, non-toxic salt form of niclosamide that acts as a reversible, mild uncoupler of mitochondria to reduce cellular energy efficiency and increase lipid oxidation. Also shown to reduce the mitochondrial membrane potential in live cells (~ 500 nM). Following oral uptake, it is distributed primarily in the liver. Improves glycemic control, improves insulin sensitivity,and reduces the level of glycated hemoglobin in C57BL/6J mice fed high fat diets. Retards the decline of plasma insulin level in db/db mice and improves their glycemic control. (150 mg/kg., p.o.). Activates AMPK and increases acetyl-CoA carboxylase phosphorylation, but does not affect the activity of gluconeogenic enzymes in the liver. Reported to reduce intracellular lipid accumulation in mice fed high fat diets.
      Catalogue Number533087
      Brand Family Calbiochem®
      SynonymsNEN
      References
      ReferencesTao, H., et al. 2014. Nat. Med. 20, 1263.
      Product Information
      FormYellow solid
      Hill FormulaC₁₃H₈Cl₂N₂O₄·C₂H₇NO
      Chemical formulaC₁₃H₈Cl₂N₂O₄·C₂H₇NO
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      533087 0

      Documentation

      Niclosamide Ethanolamine - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Tao, H., et al. 2014. Nat. Med. 20, 1263.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-March-2016 JSW
      SynonymsNEN
      DescriptionA cell permeable, orally bioavailable, non-toxic salt form of niclosamide that acts as a reversible, mild uncoupler of mitochondria to reduce cellular energy efficiency and increase lipid oxidation. Also shown to reduce the mitochondrial membrane potential in live cells (~ 500 nM). Following oral uptake, it is distributed primarily in the liver. Improves glycemic control, improves insulin sensitivity,and reduces the level of glycated hemoglobin in C57BL/6J mice fed high fat diets. Retards the decline of plasma insulin level in db/db mice and improves their glycemic control. (150 mg/kg., p.o.). Activates AMPK and increases acetyl-CoA carboxylase phosphorylation, but does not affect the activity of gluconeogenic enzymes in the liver. Reported to reduce intracellular lipid accumulation in mice fed high fat diets.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₃H₈Cl₂N₂O₄·C₂H₇NO
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTao, H., et al. 2014. Nat. Med. 20, 1263.