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12-371 Normal Mouse IgG

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12-371
250 µg  
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      Overview

      Replacement Information
      Description
      Catalogue Number12-371
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionNormal Mouse IgG
      Background InformationImmunoglobulin G (IgG), is one of the most abundant proteins in human serum with normal levels between 8-17 mg/mL in adult blood. IgG is important for our defence against microorganisms and the molecules are produced by B lymphocytes as a part of our adaptive immune response. The IgG molecule has two separate functions; to bind to the pathogen that elicited the response and to recruit other cells and molecules to destroy the antigen. The variability of the IgG pool is generated by somatic recombination and the number of specificities in an individual at a given time point is estimated to be 1011 variants.
      Normal mouse IgG was isolated from pooled normal mouse serum by fractionation and ion-exchange chromatography.
      References
      Product Information
      FormatUnconjugated
      HS Code3002 12 29
      PresentationPurified mouse IgG in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide containing 30% glycerol. Liquid at -20°C.
      Quality LevelMQ100
      Applications
      ApplicationNormal Mouse IgG Polyclonal Antibody control validated for use in Immunoprecipitation & Western Blotting.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      EpitopeN/A
      Concentration1 mg/mL
      HostMouse
      IsotypeIgG
      Antibody TypePolyclonal Antibody
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by IP/WB as a negative non-specific IgG control.

      Immunoprecipitation/Western Blot Assay:
      4 µg of this lot was used as a negative non-specific IgG control in an immunoprecipitation/western blot assay.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      For maximum recovery of product centrifuge the original vial prior to removing the cap. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size250 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      12-371 04053252676949

      Documentation

      Normal Mouse IgG SDS

      Title

      Safety Data Sheet (SDS) 

      Normal Mouse IgG Certificates of Analysis

      TitleLot Number
      Normal Mouse IgG - 2391022 2391022
      Normal Mouse IgG - 2455683 2455683
      Normal Mouse IgG - 0606033102 0606033102
      Normal Mouse IgG - 0609040161 0609040161
      Normal Mouse IgG - 19007 19007
      Normal Mouse IgG - 1951657 1951657
      Normal Mouse IgG - 2017311 2017311
      Normal Mouse IgG - 2054863 2054863
      Normal Mouse IgG - 23281 23281
      Normal Mouse IgG - 24184 24184

      References

      Reference overviewApplicationSpeciesPub Med ID
      An insulator element located at the cyclin B1 interacting protein 1 gene locus is highly conserved among mammalian species.
      Yoshida, W; Tomikawa, J; Inaki, M; Kimura, H; Onodera, M; Hata, K; Nakabayashi, K
      PloS one  10  e0131204  2015

      Show Abstract
      26110280 26110280
      Splicing function of mitotic regulators links R-loop-mediated DNA damage to tumor cell killing.
      Wan, Y; Zheng, X; Chen, H; Guo, Y; Jiang, H; He, X; Zhu, X; Zheng, Y
      The Journal of cell biology  209  235-46  2015

      Show Abstract
      25918225 25918225
      Ezh2 mediated H3K27me3 activity facilitates somatic transition during human pluripotent reprogramming.
      Rao, RA; Dhele, N; Cheemadan, S; Ketkar, A; Jayandharan, GR; Palakodeti, D; Rampalli, S
      Scientific reports  5  8229  2015

      Show Abstract
      25648270 25648270
      Characterization of the mammalian miRNA turnover landscape.
      Guo, Y; Liu, J; Elfenbein, SJ; Ma, Y; Zhong, M; Qiu, C; Ding, Y; Lu, J
      Nucleic acids research  43  2326-41  2015

      Show Abstract
      25653157 25653157
      Histone monoubiquitination by Clock-Bmal1 complex marks Per1 and Per2 genes for circadian feedback.
      Tamayo, AG; Duong, HA; Robles, MS; Mann, M; Weitz, CJ
      Nature structural & molecular biology  22  759-66  2015

      Show Abstract
      26323038 26323038
      The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex.
      Ji, Z; Mohammed, H; Webber, A; Ridsdale, J; Han, N; Carroll, JS; Sharrocks, AD
      Nucleic acids research  42  6232-42  2014

      Show Abstract
      24748658 24748658
      A long non-coding RNA promotes full activation of adult gene expression in the chicken α-globin domain.
      Arriaga-Canon, C; Fonseca-Guzmán, Y; Valdes-Quezada, C; Arzate-Mejía, R; Guerrero, G; Recillas-Targa, F
      Epigenetics  9  173-81  2014

      Show Abstract
      24196393 24196393
      Oxidative stress and inflammation modulate Rev-erbα signaling in the neonatal lung and affect circadian rhythmicity.
      Yang, G; Wright, CJ; Hinson, MD; Fernando, AP; Sengupta, S; Biswas, C; La, P; Dennery, PA
      Antioxid Redox Signal  21  17-32  2014

      Show Abstract
      24252172 24252172
      The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation.
      Zahreddine, HA; Culjkovic-Kraljacic, B; Assouline, S; Gendron, P; Romeo, AA; Morris, SJ; Cormack, G; Jaquith, JB; Cerchietti, L; Cocolakis, E; Amri, A; Bergeron, J; Leber, B; Becker, MW; Pei, S; Jordan, CT; Miller, WH; Borden, KL
      Nature  511  90-3  2014

      Show Abstract
      Immunoprecipitation24870236 24870236
      p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes.
      Benson, EK; Mungamuri, SK; Attie, O; Kracikova, M; Sachidanandam, R; Manfredi, JJ; Aaronson, SA
      Oncogene  33  3959-69  2014

      Show Abstract
      Western Blotting24096481 24096481

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      Categories

      Life Science Research > Antibodies and Assays > Negative Control / Isotype Control Antibodies