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4995
Sigma-AldrichOuabain, Octahydrate - CAS 11018-89-6 - Calbiochem
Ouabain, Octahydrate, CAS 11018-89-6, is an inhibitor of Na+,K+-ATPase. Exhibits cardiotonic properties and enhances radiotoxicity in tumor cells to induce apoptosis.
More>>Ouabain, Octahydrate, CAS 11018-89-6, is an inhibitor of Na+,K+-ATPase. Exhibits cardiotonic properties and enhances radiotoxicity in tumor cells to induce apoptosis. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
Inhibits Na+,K+-ATPase. Exhibits cardiotonic properties. Preferentially enhances radiotoxicity in tumor cells and induces apoptosis by prolonging the irradiation-induced G2 delay.
Catalogue Number
4995
Brand Family
Calbiochem®
Synonyms
Strophanthin G
References
References
Verheye-Dua, F.A., and Bohm, L. 2000. Strahlenther Onkol. 176, 186. Hasenauer, J., et al. 1993. J. Biol. Chem.268, 3289. Rakowski, F.F. 1993. J. Gen. Physiol.101, 117. Mahaney, J.E., and Grisham, C.M. 1992. Biochemistry31, 2025. Xu, Z.J., et al. 1992. J. Physiol.456, 405.
Ouabain, Octahydrate, CAS 11018-89-6, is an inhibitor of Na+,K+-ATPase. Exhibits cardiotonic properties and enhances radiotoxicity in tumor cells to induce apoptosis.
Biological Information
Primary Target
Na+,K+-ATPase
Purity
≥95% by HPLC
Physicochemical Information
Cell permeable
N
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECS
RN3850000
Safety Information
R Phrase
R: 26/27/28
Very toxic by inhalation, in contact with skin and if swallowed.
S Phrase
S: 36/37/39-45
Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 2 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number
GTIN
4995-1GM
04055977199253
Documentation
Ouabain, Octahydrate - CAS 11018-89-6 - Calbiochem SDS
Ouabain, Octahydrate - CAS 11018-89-6 - Calbiochem Certificates of Analysis
Title
Lot Number
4995
References
Reference overview
Verheye-Dua, F.A., and Bohm, L. 2000. Strahlenther Onkol. 176, 186. Hasenauer, J., et al. 1993. J. Biol. Chem.268, 3289. Rakowski, F.F. 1993. J. Gen. Physiol.101, 117. Mahaney, J.E., and Grisham, C.M. 1992. Biochemistry31, 2025. Xu, Z.J., et al. 1992. J. Physiol.456, 405.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
27-January-2014 JSW
Synonyms
Strophanthin G
Description
Inhibits Na+ and K+-dependent ATPases. Has cardiotonic properties.
Form
White to off-white solid
CAS number
11018-89-6
RTECS
RN3850000
Chemical formula
C₂₉H₄₄O₁₂ · 8H₂O
Structure formula
Purity
≥95% by HPLC
Solubility
Hot H₂O (10 mg/ml). Not soluble in room temperature water.
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 2 months at -20°C.
Toxicity
Toxic
Merck USA index
14 6901
References
Verheye-Dua, F.A., and Bohm, L. 2000. Strahlenther Onkol. 176, 186. Hasenauer, J., et al. 1993. J. Biol. Chem.268, 3289. Rakowski, F.F. 1993. J. Gen. Physiol.101, 117. Mahaney, J.E., and Grisham, C.M. 1992. Biochemistry31, 2025. Xu, Z.J., et al. 1992. J. Physiol.456, 405.
