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513020 PD 145065 - CAS 153049-49-1 - Calbiochem

A highly potent but non-selective endothelin receptor antagonist [IC₅₀= 4 nM for the ETA receptor (rabbit renal artery vascular smooth muscle cells); IC₅₀ = 15 nM for the ETB receptor (rat cerebellum)].

PD 145065 - CAS 153049-49-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Endothelin receptor antagonist
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      153049-49-1C₅₂H₆₃N₇O₁₀ · 2Na
      Description
      Overview

      This product has been discontinued.



      A highly potent but non-selective endothelin receptor antagonist [IC50 = 4 nM for the ETA receptor (rabbit renal artery vascular smooth muscle cells); IC50 = 15 nM for the ETB receptor (rat cerebellum)].
      Catalogue Number513020
      Brand Family Calbiochem®
      References
      ReferencesHan, H.K., et al. 1998. Life Sci. 63, 1599.
      Allcock, G.H., et al. 1995. Br. J. Pharmacol. 116, 2482.
      Wellings, R.P., et al. 1994. Eur. J. Pharmacol. 256, 201.
      Cody, W.L., et al. 1993. Med. Chem. Res. 3, 154.
      Doherty, A.M., et al. 1993. J. Cardiovasc. Pharmacol. 22, S98 (Suppl.).
      Product Information
      CAS number153049-49-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₅₂H₆₃N₇O₁₀ · 2Na
      Chemical formulaC₅₂H₆₃N₇O₁₀ · 2Na
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetEndothelin receptor antagonist
      Primary Target IC<sub>50</sub>4 nM against endothelin receptor (ETA receptor) in rabbit renal artery vascular smooth muscle cells; 15 nM for the ETB receptor (rat cerebellum)
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceAc-D-Bhg-Leu-Asp-Ile-Ile-Trp-OH (Bhg = 5H-dibenzo[a,d]cycloheptene-5-glycine)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 4 months at -20°C. Avoid freeze/thaw cycles of solutions.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      513020 0

      Documentation

      PD 145065 - CAS 153049-49-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PD 145065 - CAS 153049-49-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      513020

      References

      Reference overview
      Han, H.K., et al. 1998. Life Sci. 63, 1599.
      Allcock, G.H., et al. 1995. Br. J. Pharmacol. 116, 2482.
      Wellings, R.P., et al. 1994. Eur. J. Pharmacol. 256, 201.
      Cody, W.L., et al. 1993. Med. Chem. Res. 3, 154.
      Doherty, A.M., et al. 1993. J. Cardiovasc. Pharmacol. 22, S98 (Suppl.).
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-August-2008 RFH
      DescriptionA highly potent but non-selective endothelin receptor antagonist [IC50 = 4 nM for the ETA receptor (rabbit renal artery vascular smooth muscle cells); IC50 = 15 nM for ETB receptor (rat cerebellum)].
      FormWhite solid
      CAS number153049-49-1
      Chemical formulaC₅₂H₆₃N₇O₁₀ · 2Na
      Peptide SequenceAc-D-Bhg-Leu-Asp-Ile-Ile-Trp-OH (Bhg = 5H-dibenzo[a,d]cycloheptene-5-glycine)
      Purity≥98% by HPLC
      SolubilityPhosphate buffer, pH 7.5 (1 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 4 months at -20°C. Avoid freeze/thaw cycles of solutions.
      Toxicity Standard Handling
      ReferencesHan, H.K., et al. 1998. Life Sci. 63, 1599.
      Allcock, G.H., et al. 1995. Br. J. Pharmacol. 116, 2482.
      Wellings, R.P., et al. 1994. Eur. J. Pharmacol. 256, 201.
      Cody, W.L., et al. 1993. Med. Chem. Res. 3, 154.
      Doherty, A.M., et al. 1993. J. Cardiovasc. Pharmacol. 22, S98 (Suppl.).