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521235 PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem

The PDGFR Tyrosine Kinase Inhibitor VI, SU6668, also referenced under CAS 210644-62-5, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (Z)-3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl)-propionic acid, mTOR Inhibitor X, VEGFR Tyrosine Kinase Inhibitor XXVII, VEGFR2 Kinase Inhibitor XXV, Aurora Kinase Inhibitor IV

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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      210644-62-5C₁₈H₁₈N₂O₃
      Description
      Overview

      This product has been discontinued.



      A cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC50 = 0.01, 0.1, 3.9, and 3.8 µM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development in vivo. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC50 = 0.85, 0.047, 1.4, and 1.8 µM, respectively), as well as non-receptor TKs Lyn and Yes (IC50 = 4.3 and 5.8 µM, respectively).
      Catalogue Number521235
      Brand Family Calbiochem®
      Synonyms(Z)-3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl)-propionic acid, mTOR Inhibitor X, VEGFR Tyrosine Kinase Inhibitor XXVII, VEGFR2 Kinase Inhibitor XXV, Aurora Kinase Inhibitor IV
      References
      ReferencesGodl, K., et al. 2005. Cancer Res. 65, 6919.
      Laird, A.D., et al. 2002. FASEB J. 16, 681.
      Krystal, G.W., et al. 2001. Cancer Res. 61, 3660.
      Smolich, B.D., et al. 2001. Blood 97, 1413.
      Laird, A.D., et al. 2000. Cancer Res. 60, 4152.
      Shaheen, R.M., et al. 1999. Cancer Res. 59, 5412.
      Sun, L. et al. 1999. J. Med. Chem. 42, 5120.
      Product Information
      CAS number210644-62-5
      FormDark yellow solid
      Hill FormulaC₁₈H₁₈N₂O₃
      Chemical formulaC₁₈H₁₈N₂O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22-36/37/38

      Harmful if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      521235 0

      Documentation

      PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      521235

      References

      Reference overview
      Godl, K., et al. 2005. Cancer Res. 65, 6919.
      Laird, A.D., et al. 2002. FASEB J. 16, 681.
      Krystal, G.W., et al. 2001. Cancer Res. 61, 3660.
      Smolich, B.D., et al. 2001. Blood 97, 1413.
      Laird, A.D., et al. 2000. Cancer Res. 60, 4152.
      Shaheen, R.M., et al. 1999. Cancer Res. 59, 5412.
      Sun, L. et al. 1999. J. Med. Chem. 42, 5120.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-April-2009 RFH
      Synonyms(Z)-3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl)-propionic acid, mTOR Inhibitor X, VEGFR Tyrosine Kinase Inhibitor XXVII, VEGFR2 Kinase Inhibitor XXV, Aurora Kinase Inhibitor IV
      DescriptionA cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC50 = 0.01, 0.1, 3.9, and 3.8 µM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development in vivo. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC50 = 0.85, 0.047, 1.4, and 1.8 µM, respectively), as well as non-receptor TKs Lyn and Yes (IC50 = 4.3 and 5.8 µM, respectively).
      FormDark yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number210644-62-5
      Chemical formulaC₁₈H₁₈N₂O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      ReferencesGodl, K., et al. 2005. Cancer Res. 65, 6919.
      Laird, A.D., et al. 2002. FASEB J. 16, 681.
      Krystal, G.W., et al. 2001. Cancer Res. 61, 3660.
      Smolich, B.D., et al. 2001. Blood 97, 1413.
      Laird, A.D., et al. 2000. Cancer Res. 60, 4152.
      Shaheen, R.M., et al. 1999. Cancer Res. 59, 5412.
      Sun, L. et al. 1999. J. Med. Chem. 42, 5120.