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529579 PP1 Analog - CAS 221243-82-9 - Calbiochem

PP1 Analog - CAS 221243-82-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-Amino-1-tert-butyl-3-(1ʹ-naphthyl)pyrazolo[3,4-d]pyrimidine, 1-Na PP1, 1-NA-PP1

Primary Target: I338G mutant v-Src
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      221243-82-9C₁₉H₁₉N₅
      Description
      OverviewA potent, reversible, ATP-competitive, and cell-permeable inhibitor of Src-family tyrosine kinases that is > 800 times more selective for the I338G mutant v-Src (IC50 = 1.5 nM) compared to wild-type v-Src (IC50 = 1.0 µM). Also inhibits wild-type Fyn (IC50 = 600 nM). Also available in InSolution™ format (Cat. No. 529605).
      Catalogue Number529579
      Brand Family Calbiochem®
      Synonyms4-Amino-1-tert-butyl-3-(1ʹ-naphthyl)pyrazolo[3,4-d]pyrimidine, 1-Na PP1, 1-NA-PP1
      References
      ReferencesBishop, A.C., et al. 2000. Nature 407, 395.
      Bishop, A.C., et al. 1999 J. Am. Chem. Soc. 121, 627.
      Product Information
      CAS number221243-82-9
      ATP CompetitiveY
      Declaration

      Not available for sale in the United States.
      FormOff-white solid
      Hill FormulaC₁₉H₁₉N₅
      Chemical formulaC₁₉H₁₉N₅
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetI338G mutant v-Src
      Primary Target IC<sub>50</sub>1.5 nM against I338G mutant v-Src; 1.0 µM against wild-type v-Src; 600 nM against wild-type Fyn
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      529579 0

      Documentation

      PP1 Analog - CAS 221243-82-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PP1 Analog - CAS 221243-82-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      529579

      References

      Reference overview
      Bishop, A.C., et al. 2000. Nature 407, 395.
      Bishop, A.C., et al. 1999 J. Am. Chem. Soc. 121, 627.

      Citations

      Title
    • Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-January-2012 RFH
      Synonyms4-Amino-1-tert-butyl-3-(1ʹ-naphthyl)pyrazolo[3,4-d]pyrimidine, 1-Na PP1, 1-NA-PP1
      DescriptionA potent, reversible, ATP-competitive, cell-permeable and selective inhibitor of Src-family tyrosine kinases that is > 800 times more selective for the I338G mutant v-Src (IC50 = 1.5 nM) compared to wild-type v-Src (IC50 = 1 µM). Also inhibits wild-type Fyn (IC50 = 600 nM). Also available in InSolution™ format (Cat. No. 529605).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number221243-82-9
      Chemical formulaC₁₉H₁₉N₅
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
      Toxicity Standard Handling
      ReferencesBishop, A.C., et al. 2000. Nature 407, 395.
      Bishop, A.C., et al. 1999 J. Am. Chem. Soc. 121, 627.
      Citation
    • Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
      		•