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516090 Penciclovir - CAS 39809-25-1 - Calbiochem

A carba analog of Ganciclovir. Active against several herpes viruses. Induces apoptosis effectively without exerting much genotoxicity.

Penciclovir - CAS 39809-25-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one

516090
  
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      39809-25-1C₁₀H₁₅N₅O₃
      Description
      OverviewA carba analog of Ganciclovir (Cat. No. 345700). Active against several herpes viruses (IC50 = 37.9 µM for HHV-6A and 77.8 µM for HHV-6B). Induces apoptosis effectively without exerting much genotoxicity.
      Catalogue Number516090
      Brand Family Calbiochem®
      Synonyms2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one
      References
      ReferencesLeary, J.J., et al. 2002.Antimicrob. Agents Chemother. 46, 762.
      Amjad, M., et al. 2001. Microbiol. Immunol. 45, 233.
      Thust, R., et al. 2000. Cancer Gene Ther. 7, 107.
      Thust, R., et al. 1996. Antiviral Res. 31, 105.
      Shaw, T., et al. 1994. Antimicrob. Agents Chemother. 38, 719.
      Harnden, M.R. 1989. J. Med. Chem. 32, 1738.
      Product Information
      CAS number39809-25-1
      FormWhite solid
      Hill FormulaC₁₀H₁₅N₅O₃
      Chemical formulaC₁₀H₁₅N₅O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 46-60-61

      May cause heritable genetic damage.
      May impair fertility.
      May cause harm to the unborn child.
      S PhraseS: 36/37/39-45-53

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Avoid exposure - obtain special instructions before use.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      516090 0

      Documentation

      Penciclovir - CAS 39809-25-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Penciclovir - CAS 39809-25-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      516090

      References

      Reference overview
      Leary, J.J., et al. 2002.Antimicrob. Agents Chemother. 46, 762.
      Amjad, M., et al. 2001. Microbiol. Immunol. 45, 233.
      Thust, R., et al. 2000. Cancer Gene Ther. 7, 107.
      Thust, R., et al. 1996. Antiviral Res. 31, 105.
      Shaw, T., et al. 1994. Antimicrob. Agents Chemother. 38, 719.
      Harnden, M.R. 1989. J. Med. Chem. 32, 1738.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-May-2008 RFH
      Synonyms2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one
      DescriptionA synthetic acyclic guanine derivative and a carba analog of Ganciclovir (Cat. No. 345700) that is active against several herpes viruses (IC50 = 37.9 µM for HHV-6A and 77.8 µM for HHV-6B). Induces apoptosis effectively without exerting much genotoxicity.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number39809-25-1
      Chemical formulaC₁₀H₁₅N₅O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityAqueous buffer, pH 2.0 (10 mg/ml) or H₂O (1 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index15, 7083
      ReferencesLeary, J.J., et al. 2002.Antimicrob. Agents Chemother. 46, 762.
      Amjad, M., et al. 2001. Microbiol. Immunol. 45, 233.
      Thust, R., et al. 2000. Cancer Gene Ther. 7, 107.
      Thust, R., et al. 1996. Antiviral Res. 31, 105.
      Shaw, T., et al. 1994. Antimicrob. Agents Chemother. 38, 719.
      Harnden, M.R. 1989. J. Med. Chem. 32, 1738.