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531294 Perk Inhibitor III, LDN-0070977 - Calbiochem

A cell-permeable, reversible, and non ATP-competitive inhibitor of PERK (PKR-like ER kinase, IC₅₀ = 7.04 µM) and blocks PERK-dependent phosphorylation of elF2a.

Perk Inhibitor III, LDN-0070977 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PKR-like ER kinase Inhibitor, LDN-0070977, LDN0070977, LDN 0070977

Primary Target: PERK
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₂H₈N₂O
      Description
      Overview

      This product has been discontinued.



      A cell-permeable tricyclic heterocycle oxime that acts as a reversible and non ATP-competitive inhibitor of PERK (PKR-like ER kinase, IC50 = 7.04 µM) and blocks PERK-dependent phosphorylation of elF2a. Shown to reduce thapsigargin-induced elF2a phosphorylation in mouse embryonic fibroblasts over a wide range. Does not exhibit any cellular toxicity up to 50 µM levels.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.

      Catalogue Number531294
      Brand Family Calbiochem®
      SynonymsPKR-like ER kinase Inhibitor, LDN-0070977, LDN0070977, LDN 0070977
      References
      ReferencesPytel, D., et al. 2014. J. Biomol. Screen. 19, 1024.
      Product Information
      FormOff-white powder
      Hill FormulaC₁₂H₈N₂O
      Chemical formulaC₁₂H₈N₂O
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPERK
      Primary Target IC<sub>50</sub>7µ
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      531294 0

      Documentation

      Perk Inhibitor III, LDN-0070977 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Pytel, D., et al. 2014. J. Biomol. Screen. 19, 1024.

      Technical Info

      Title
      Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
      White Paper: Further considerations of antibody validation and usage.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-March-2015 JSW
      SynonymsPKR-like ER kinase Inhibitor, LDN-0070977, LDN0070977, LDN 0070977
      DescriptionA cell-permeable tricyclic heterocycle oxime that acts as a reversible and non ATP-competitive inhibitor of PERK (PKR-like ER kinase, IC50 = 7.04 µM) and blocks PERK-dependent phosphorylation of elF2a. Shown to reduce thapsigargin-induced elF2a phosphorylation in mouse embryonic fibroblasts over a wide range. Does not exhibit any cellular toxicity up to 50 µM levels.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₂H₈N₂O
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesPytel, D., et al. 2014. J. Biomol. Screen. 19, 1024.