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516852 Pertussis Toxin, B Oligomer, Bordetella pertussis - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
516852
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.



      The pentameric cell-binding component that is responsible for binding of the holotoxin to eukaryotic cell surfaces, facilitating entry of the A protomer into receptive cells. Reported to elicit direct cellular responses by binding to several cell surface receptors with oligosaccharide side chains. Also elicits a variety of physiological responses, such as mitogenesis in human T cells, enhancement of aggregation of human platelets, elevation of cytosolic Ca2+ levels, and neutralization of antibody response in mice. Reported to deactivate CCR5 and inhibit the entry of R5 HIV-1 in activated T lymphocytes. Also blocks post-entry step of HIV-1 replication.
      Catalogue Number516852
      Brand Family Calbiochem®
      References
      ReferencesAlfano, M., et al. 2001. J. Immunol. 166, 1863.
      Alfano, M., et al. 2000. J. Virol. 74, 8767.
      Hazes, B., et al. 1996. J. Mol. Biol. 258, 661.
      Wong, W.S., and Rosoff, P.M. 1996. Can. J. Physiol. Pharmacol. 74, 559.
      Banga, S., et al. 1987. J. Biol. Chem. 262, 14871.
      Burns, D.L., et al. 1987. Infect. Immun. 55, 24.
      Hewlett, E.L., et al. 1983. Infect. Immun. 40, 1198.
      Sato, Y., et al. 1983. Infect. Immun. 41, 313.
      Tamura, M., et al. 1982. Biochemistry 21, 5516.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      ReversibleN
      Applications
      Biological Information
      Primary TargetCell surface receptors with oligosaccharide side chains
      PurityFour distinct bands by SDS-PAGE
      Physicochemical Information
      Cell permeableN
      Contaminants≤1% holotoxin by CHO cell assay
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 23/24/25

      Toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 45-36/37/39

      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions, prepared from high ionic strength buffers, are stable for up to 3 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      516852 0

      Documentation

      Pertussis Toxin, B Oligomer, Bordetella pertussis - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Pertussis Toxin, B Oligomer, Bordetella pertussis - Calbiochem Certificates of Analysis

      TitleLot Number
      516852

      References

      Reference overview
      Alfano, M., et al. 2001. J. Immunol. 166, 1863.
      Alfano, M., et al. 2000. J. Virol. 74, 8767.
      Hazes, B., et al. 1996. J. Mol. Biol. 258, 661.
      Wong, W.S., and Rosoff, P.M. 1996. Can. J. Physiol. Pharmacol. 74, 559.
      Banga, S., et al. 1987. J. Biol. Chem. 262, 14871.
      Burns, D.L., et al. 1987. Infect. Immun. 55, 24.
      Hewlett, E.L., et al. 1983. Infect. Immun. 40, 1198.
      Sato, Y., et al. 1983. Infect. Immun. 41, 313.
      Tamura, M., et al. 1982. Biochemistry 21, 5516.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-August-2008 RFH
      DescriptionThe pentameric cell-binding component that is responsible for binding of the holotoxin to eukaryotic cell surfaces, facilitating entry of the A protomer into receptive cells. Reported to elicit direct cellular responses by binding to several cell surface receptors with oligosaccharide side chains. Also causes a variety of physiological responses, such as mitogenesis in human T-cells, enhancement of aggregation of human platelets, elevation of cytosolic Ca2+ levels, and neutralization of antibody response in mice.
      FormLyophilized
      PurityFour distinct bands by SDS-PAGE
      Contaminants≤1% holotoxin by CHO cell assay
      SolubilitySterile distilled H₂O or aqueous buffers
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions, prepared from high ionic strength buffers, are stable for up to 3 months at 4°C.
      Toxicity Toxic
      ReferencesAlfano, M., et al. 2001. J. Immunol. 166, 1863.
      Alfano, M., et al. 2000. J. Virol. 74, 8767.
      Hazes, B., et al. 1996. J. Mol. Biol. 258, 661.
      Wong, W.S., and Rosoff, P.M. 1996. Can. J. Physiol. Pharmacol. 74, 559.
      Banga, S., et al. 1987. J. Biol. Chem. 262, 14871.
      Burns, D.L., et al. 1987. Infect. Immun. 55, 24.
      Hewlett, E.L., et al. 1983. Infect. Immun. 40, 1198.
      Sato, Y., et al. 1983. Infect. Immun. 41, 313.
      Tamura, M., et al. 1982. Biochemistry 21, 5516.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Biochemicals > Toxins