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524714 Phosphodiesterase V Inhibitor II

Phosphodiesterase V Inhibitor II MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PDE V Inhibitor II

524714
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.

      Please refer to our complete listing of phosphodiesterase inhibitors for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.





      A cell-permeable tetrahydro-β-carboline-hydantoin compound that acts as a potent and highly selective phosphodiesterase V inhibitor (IC50 = 5 nM for bovine aorta PDE V; IC50 > 10 µM for human recombinant PDE I & III, and for bovine aorta PDE II & IV]. Shown to increase intracellular cGMP levels in ANF-treated RSMC (EC50 = 1 µM) and significantly lower blood pressure in a spontaneously hypertensive rat model in vivo.
      Catalogue Number524714
      Brand Family Calbiochem®
      SynonymsPDE V Inhibitor II
      References
      ReferencesDaugan, A., et al. 2003. J. Med. Chem. 46, 4533. Daugan, A., et al. 2003. J. Med. Chem. 46, 4525.
      Product Information
      FormWhite solid
      Hill FormulaC₂₄H₂₅N₃O₃
      Chemical formulaC₂₄H₂₅N₃O₃
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Targetbovine aorta PDEV
      Primary Target IC<sub>50</sub>5 nM
      Secondary targetIC₅₀ > 10 µM for human recombinant PDE I & III, and for bovine aorta PDE II & IV
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      524714 0

      Documentation

      Phosphodiesterase V Inhibitor II Certificates of Analysis

      TitleLot Number
      524714

      References

      Reference overview
      Daugan, A., et al. 2003. J. Med. Chem. 46, 4533. Daugan, A., et al. 2003. J. Med. Chem. 46, 4525.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-August-2008 RFH
      SynonymsPDE V Inhibitor II
      DescriptionA cell-permeable tetrahydro-b-carboline-hydantoin compound that acts as a potent and highly selective phosphodiesterase V inhibitor (IC50 = 5 nM for bovine aorta PDE V; >10 µM for human recombinant PDE1 and PDE III and bovine aorta PDE II and PDE IV). Reported to increase intracellular cGMP levels in ANF-treated rat smooth muscle cells (RSMC) (EC50 = 1 µM). Also reported to lower blood pressure in a spontaneously hypertensive rat model in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₄H₂₅N₃O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml) or ethanol
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDaugan, A., et al. 2003. J. Med. Chem. 46, 4533. Daugan, A., et al. 2003. J. Med. Chem. 46, 4525.