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5291 Polymyxin B Sulfate - CAS 1405-20-5 - Calbiochem

Polymyxin B Sulfate, CAS 1405-20-5, is an antibiotic that is effective against Gram-positive bacteria. Inhibits phospholipid-sensitive Ca2+-dependent protein kinases.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Aerosporin

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      Overview

      Replacement Information

      Key Specifications Table

      CAS #
      1405-20-5
      Description
      OverviewAn antibiotic that inhibits phospholipid-sensitive Ca2+-dependent protein kinases. Mixture of polymyxin B1 sulfate and polymyxin B2 sulfate. Binds to cell wall and makes it more permeable, causing fluid uptake. Effective against Gram-negative bacteria.
      Catalogue Number5291
      Brand Family Calbiochem®
      SynonymsAerosporin
      References
      ReferencesLucas, M., et al. 1994. Biochem. Pharmacol. 47, 667.
      Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch. 422, 413.
      Kubo, M. and Okada, Y. 1992. J. Physiol. 456, 351.
      Strasser, S.H., et al. 1992. Circ. Res. 70, 1304.
      Hegemann, L., et al. 1991. Eur. J. Pharmacol. 207, 17.
      Inaba, H. and Filkins, J.P. 1991. Am. J. Physiol. 261, R26.
      Marra, M.N., et al. 1990. J. Immunol. 144, 662.
      Product Information
      CAS number1405-20-5
      FormWhite to off-white solid
      Quality LevelMQ200
      Applications
      Biological Information
      Biological activityPotency: ≥7500 IU/mg
      Primary TargetPhospholipid sensitive Ca2+ dependent protein kinases
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSTR1150000
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 year at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      5291 0

      Documentation

      Polymyxin B Sulfate - CAS 1405-20-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Polymyxin B Sulfate - CAS 1405-20-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      5291

      References

      Reference overview
      Lucas, M., et al. 1994. Biochem. Pharmacol. 47, 667.
      Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch. 422, 413.
      Kubo, M. and Okada, Y. 1992. J. Physiol. 456, 351.
      Strasser, S.H., et al. 1992. Circ. Res. 70, 1304.
      Hegemann, L., et al. 1991. Eur. J. Pharmacol. 207, 17.
      Inaba, H. and Filkins, J.P. 1991. Am. J. Physiol. 261, R26.
      Marra, M.N., et al. 1990. J. Immunol. 144, 662.

      Brochure

      Title
      Antibiotics Profiler
      PKC Pathway Poster PDF ( 676 KB )
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-January-2011 JSW
      SynonymsAerosporin
      DescriptionAn antibiotic that inhibits phospholipid sensitive Ca2+-dependent protein kinase. Mixture of polymyxin B1 sulfate and polymyxin B2 sulfate.
      FormWhite to off-white solid
      CAS number1405-20-5
      RTECSTR1150000
      Biological activityPotency: ≥7500 IU/mg
      SolubilityH₂O (25 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 year at -20°C.
      Toxicity Harmful
      Merck USA index14, 7573
      ReferencesLucas, M., et al. 1994. Biochem. Pharmacol. 47, 667.
      Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch. 422, 413.
      Kubo, M. and Okada, Y. 1992. J. Physiol. 456, 351.
      Strasser, S.H., et al. 1992. Circ. Res. 70, 1304.
      Hegemann, L., et al. 1991. Eur. J. Pharmacol. 207, 17.
      Inaba, H. and Filkins, J.P. 1991. Am. J. Physiol. 261, R26.
      Marra, M.N., et al. 1990. J. Immunol. 144, 662.

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      Categories

      Life Science Research > Cell Culture and Systems > Antibiotics & Selection Agents
      Life Science Research > Inhibitors and Biochemicals > Biochemicals > Antibiotics > Antimicrobial Agents