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540220 Purmorphamine - CAS 483367-10-8 - Calbiochem

Overview

Key Specifications Table

CAS #Empirical Formula
483367-10-8C₃₁H₃₂N₆O₂

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
540220-20MG
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      Glass bottle 20 mg
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      540220-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable 2,6,9-trisubstituted purine compound that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC50 = 1 µM) and lineage-committed preosteoblasts MC3T3-E1. Its effect can be synergized with that of BMP-4 (bone morphogenetic protein-4) and has been shown to induce transdifferentiation even in preadipocytes and myoblasts. Reported to induce osteogenesis by activation of the Hedgehog signaling pathway. A 50 mM (5 mg/192 µl) solution of Purmorphamine (Cat. No. 540223) in DMSO is also available.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number540220
          Brand Family Calbiochem®
          Synonyms2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine, Shh Signaling Agonist
          References
          ReferencesWu, X., et al. 2004. Chem. Biol. 11, 1229.
          Wu, X., et al. 2002. J. Am. Chem. Soc. 124, 14520.
          Product Information
          CAS number483367-10-8
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₃₁H₃₂N₆O₂
          Chemical formulaC₃₁H₃₂N₆O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Biological Information
          Primary TargetActivation of the Hedgehog signaling pathway
          Primary Target IC<sub>50</sub>EC50 = 1 µM for inducing osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Safety Information
          R PhraseR: 22-68

          Harmful if swallowed.
          Possible risks of irreversible effects.
          S PhraseS: 22-36/37

          Do not breathe dust.
          Wear suitable protective clothing and gloves.
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Global Trade Item Number
          Catalog Number GTIN
          540220-20MG 04055977268737
          540220-5MG 07790788051389