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559399 SB 203580, Sulfone - CAS 152121-46-5 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridyl)-1H-imidazole, p38 MAP Kinase Inhibitor XII

Primary Target: P38K
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      152121-46-5C₂₁H₁₆FN₃O₂S
      Description
      Overview

      This product has been discontinued.



      A cell permeable, reversible, and ATP-competitive sulfone analog of the p38 MAP kinase inhibitor SB 203580 (Cat. No. 559389). Potently inhibits p38 kinase (IC50 = 30 nM) and inhibits IL-1 production in human monocytes (IC50 = 200 nM).
      Catalogue Number559399
      Brand Family Calbiochem®
      Synonyms4-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridyl)-1H-imidazole, p38 MAP Kinase Inhibitor XII
      References
      ReferencesGallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
      Product Information
      CAS number152121-46-5
      ATP CompetitiveY
      FormPale yellow solid
      Hill FormulaC₂₁H₁₆FN₃O₂S
      Chemical formulaC₂₁H₁₆FN₃O₂S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetP38K
      Primary Target IC<sub>50</sub>30 nM and 200 nM against p38 kinase and IL-1 production, respectively, in human monocytes.
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      559399 0

      Documentation

      SB 203580, Sulfone - CAS 152121-46-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      SB 203580, Sulfone - CAS 152121-46-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      559399

      References

      Reference overview
      Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.

      Brochure

      Title
      MAPK Pathway Poster ( 750 KB )
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-January-2010 RFH
      Synonyms4-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridyl)-1H-imidazole, p38 MAP Kinase Inhibitor XII
      DescriptionA cell permeable, reversible, and ATP-competitive sulfone metabolite of the p38 MAP kinase inhibitor, SB 203580 (Cat. No. 559389). Potently inhibits p38 MAP kinase (IC50 = 30 nM). Also inhibits IL-1 production in human monocytes (IC50 = 200 nM).
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number152121-46-5
      Chemical formulaC₂₁H₁₆FN₃O₂S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesGallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.