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SCC262 SK-MEL-37 Human Melanoma Cell Line

SK-MEL-37 is valuable and highly characterized cell system for transformation of melanocytes into melanoma and identification of therapeutic targets for this disease.

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SCC262
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC262
      DescriptionSK-MEL-37 Human Melanoma Cell Line
      OverviewMalignant melanoma is the most aggressive type of skin cancer, and the fifth most common cancer in the Unites States.1 As survival rate depends on the stage of disease at time of diagnosis, early detection is crucial to improving disease outcome and saving lives. Amelanotic (or hypomelanotic) melanoma (AM) is a rare subtype of cutaneous melanoma, comprising between 2-8% of total cases.2 AM is characterized by decreased or null presence of melanin, due to loss of pigment in tumor evolution. AM is usually diagnosed at more advanced stages, resulting in lower overall survival. AM is frequently observed in patients with melanocortin 1 receptor gene (MC1R) genotypes linked to certain phenotypes such as red hair.2
      The SK-MEL-37 amelanotic cutaneous melanoma cell line is a well-established model for human melanoma, widely utilized in investigations into the mutational landscape of melanoma and the enhanced antigen expression that occurs concomitantly with melanoma progression. SK-MEL-37 expresses the melanoma-associated antigens MAGE-A1, tyrosinase, and p97, and cell surface antigens essential for metastasis such as CD71 and CD146.3 SK-MEL-37 is valuable and highly characterized cell system for transformation of melanocytes into melanoma and identification of therapeutic targets for this disease.

      Source
      SK-MEL-37 was established from a metastatic lymph node of a 65-year old male patient with malignant melanoma of rectal tumor origin.4

      References
      1. CA Cancer J Clin 2019, 69(1): 7-34.
      2. Cancers (Basel) 2020, 12(9): 2362.
      3. J Cancer 2013, 45(5): 371-382.
      4. J Exp Med 1976, 144(4): 873
      Alternate Names
      • SK-Mel-37
      • SK-MEL37
      • SK-MEL 37
      • SK MEL37
      • SKMEL-37
      • SK-37
      • SK37-MEL
      • BD-Mel
      Background InformationMalignant melanoma is the most aggressive type of skin cancer, and the fifth most common cancer in the Unites States.1 As survival rate depends on the stage of disease at time of diagnosis, early detection is crucial to improving disease outcome and saving lives. Amelanotic (or hypomelanotic) melanoma (AM) is a rare subtype of cutaneous melanoma, comprising between 2-8% of total cases.2 AM is characterized by decreased or null presence of melanin, due to loss of pigment in tumor evolution. AM is usually diagnosed at more advanced stages, resulting in lower overall survival. AM is frequently observed in patients with melanocortin 1 receptor gene (MC1R) genotypes linked to certain phenotypes such as red hair.2
      The SK-MEL-37 amelanotic cutaneous melanoma cell line is a well-established model for human melanoma, widely utilized in investigations into the mutational landscape of melanoma and the enhanced antigen expression that occurs concomitantly with melanoma progression. SK-MEL-37 expresses the melanoma-associated antigens MAGE-A1, tyrosinase, and p97, and cell surface antigens essential for metastasis such as CD71 and CD146.3 SK-MEL-37 is valuable and highly characterized cell system for transformation of melanocytes into melanoma and identification of therapeutic targets for this disease.

      Source
      SK-MEL-37 was established from a metastatic lymph node of a 65-year old male patient with malignant melanoma of rectal tumor origin.4

      References
      1. CA Cancer J Clin 2019, 69(1): 7-34.
      2. Cancers (Basel) 2020, 12(9): 2362.
      3. J Cancer 2013, 45(5): 371-382.
      4. J Exp Med 1976, 144(4): 873
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationSK-MEL-37 is valuable and highly characterized cell system for transformation of melanocytes into melanoma and identification of therapeutic targets for this disease.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X106 viable cells.
      • Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of human origin and negative for inter-species contamination from mouse, rat, chinese hamster, Golden Syrian hamster, and Non-human Primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
      • Cells are negative for mycoplasma contamination.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      SCC262 04065266779967